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Table 4 Associations between candidate correlating factors and CA125 level ≥ 35 U/ml among premenopausal women (N = 1157) by univariable and multivariable logistic regressions

From: Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study

Variables Univariable logistic regressionsa   Multivariable logistic regressionsb
  Effect estimate Odds ratio (OR) P value Effect estimate Standard error OR P value
Smoking
 Currentd −0.654 0.520 0.0893 −0.863 0.426 0.422 0.043
 Former 0.311 1.365 0.471 0.579 0.400 1.784 0.148
 None ref       
EtOH
  > 2 drinks/day −0.165 0.848 0.679     
 1–2 drinks/day 0.092 1.096 0.763     
 None ref       
Caffeine −0.00037 1.000 0.530     
Age of menarche
  > 12 0.118 1.125 0.634     
  ≤ 12 ref       
Breastfeedc 0.012 1.012 0.968     
CHC use −1.019 0.361 0.570     
OCP duration
 10+ years −0.483 0.617 0.407 −0.596 0.621 0.551 0.337
 5–10 yearsd − 0.967 0.380 0.098 −1.173 0.548 0.309 0.032
 2–5 years 0.528 1.695 0.234 0.465 0.474 1.592 0.327
  < 2 years ref       
CRP 0.325 1.383 0.154 0.295 0.260 1.343 0.256
Ferritin −0.00195 0.998 0.621     
Salpingectomy −0.616 0.540 0.278     
Endometriosis 0.857 2.355 0.029 0.763 0.631 2.145 0.226
Fibroids 0.456 1.578 0.468     
HLD −0.412 0.662 0.480     
Non-ovarian cancer 0.058 1.060 0.938     
  1. EtOH Alcohol, CHC Current hormonal contraception, OCP Oral contraceptive pill, CRP C reactive protein, CAD Coronary artery disease, HLD Hyperlipidemia
  2. a All univariable regressions were adjusted for baseline variables including age, race/ethnicity, BMI and parity
  3. b Multivariable regressions included the baseline variables (age, race/ethnicity, BMI, parity) and eligible variables from univariable analyses with cut-off p value < 0.25
  4. c For the “Breastfeed” variable, the reference for parity is one instead of none
  5. d These variables demonstrated significant associations with CA125 level ≥ 35 U/ml in the multivariable logistic regression model