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Table 4 Associations between candidate correlating factors and CA125 level ≥ 35 U/ml among premenopausal women (N = 1157) by univariable and multivariable logistic regressions

From: Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study

Variables

Univariable logistic regressionsa

 

Multivariable logistic regressionsb

 

Effect estimate

Odds ratio (OR)

P value

Effect estimate

Standard error

OR

P value

Smoking

 Currentd

−0.654

0.520

0.0893

−0.863

0.426

0.422

0.043

 Former

0.311

1.365

0.471

0.579

0.400

1.784

0.148

 None

ref

      

EtOH

  > 2 drinks/day

−0.165

0.848

0.679

    

 1–2 drinks/day

0.092

1.096

0.763

    

 None

ref

      

Caffeine

−0.00037

1.000

0.530

    

Age of menarche

  > 12

0.118

1.125

0.634

    

  ≤ 12

ref

      

Breastfeedc

0.012

1.012

0.968

    

CHC use

−1.019

0.361

0.570

    

OCP duration

 10+ years

−0.483

0.617

0.407

−0.596

0.621

0.551

0.337

 5–10 yearsd

− 0.967

0.380

0.098

−1.173

0.548

0.309

0.032

 2–5 years

0.528

1.695

0.234

0.465

0.474

1.592

0.327

  < 2 years

ref

      

CRP

0.325

1.383

0.154

0.295

0.260

1.343

0.256

Ferritin

−0.00195

0.998

0.621

    

Salpingectomy

−0.616

0.540

0.278

    

Endometriosis

0.857

2.355

0.029

0.763

0.631

2.145

0.226

Fibroids

0.456

1.578

0.468

    

HLD

−0.412

0.662

0.480

    

Non-ovarian cancer

0.058

1.060

0.938

    
  1. EtOH Alcohol, CHC Current hormonal contraception, OCP Oral contraceptive pill, CRP C reactive protein, CAD Coronary artery disease, HLD Hyperlipidemia
  2. a All univariable regressions were adjusted for baseline variables including age, race/ethnicity, BMI and parity
  3. b Multivariable regressions included the baseline variables (age, race/ethnicity, BMI, parity) and eligible variables from univariable analyses with cut-off p value < 0.25
  4. c For the “Breastfeed” variable, the reference for parity is one instead of none
  5. d These variables demonstrated significant associations with CA125 level ≥ 35 U/ml in the multivariable logistic regression model