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Fig. 6 | BMC Cancer

Fig. 6

From: KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development

Fig. 6

SP1 plays crucial roles in KDM3A-mediated growth and metastasis of OS cells. A proliferative activity of MG63 and HOS cells detected by the CCK-8 assay; B colony formation ability of MG63 and HOS cells examined by the colony formation assay; C migration of MG63 and HOS cells examined by the scratch test; D invasion of MG63 and HOS cells examined by the Transwell assay; E growth rate of xenograft tumors formed by HOS cells in nude mice; F weight of the xenograft tumors on day 30; G tumor infiltration in mouse lung tissues 45 days after tail vein injection of HOS cells examined by HE staining. For cellular experiments, three repetitions were performed; for animal experiments, n = 5 in each group. Data were analyzed by the unpaired t test (F-G) and two-way ANOVA (A-E) followed by Tukey’s test. *p < 0.05

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