Fig. 11From: KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor developmentGraphical presentation for the molecular mechanism. KDM3A is upregulated in OS and promotes the transcription of SP1 through demethylating H3K9me2. SP1 further activates the transcription of PFKFB4 to promote glycolytic activity in OS cells and induce tumor progressionBack to article page