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Fig. 1 | BMC Cancer

Fig. 1

From: KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development

Fig. 1

KDM3A is highly expressed in OS and indicates poor prognosis for patients. A expression profile of KDM3A in sarcoma in TCGA database; B KDM3A expression in Ewing Sarcoma and OS in the GEO GSE73166 dataset; C IHC score of KDM3A in the collected tumor and peritumor tissue samples; D-E, KDM3A mRNA (D) and protein (E) levels in the normal cells (hFOB1.19 and OPC1) and OS cell lines (MG63, Saos-2, U2OS and HOS) detected by RT-qPCR and western blot analysis. Three independent experiments were performed. Data were analyzed by the unpaired t test (B), paired t test (C), and one-way ANOVA (D and E) followed by Tukey’s test. *p < 0.05

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BMC Cancer

ISSN: 1471-2407

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