Table 2 Patients’ characteristics according to CD4+ and CD8+ T lymphopenia
From: Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer
|  | Overall population (N = 169) | Absolute TL CD4 count ≤ 500 (N = 48) | Absolute TL CD4 count > 500 (N = 121) | P | Absolute TL CD8 count ≤ 224 (N = 50) |  | Absolute TL CD8 count > 224 (N = 119) |  | P | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | N | Â | N | Â | N | Â | Â | N | Â | N | Â | |
Clinical characteristics | ||||||||||||
Age — years | 64.5 (57.5 - + 70.5) | 169 | 65.5 (60.5–76.6) | 48 | 63.7 (56.9–69.7) | 121 | 0.0532 | 65.7 (61.9–72.1) | 50 | 63.3 (56.8–70.5) | 119 | 0.0925 |
Patient male sex | 110 (65%) | 169 | 33 (69%) | 48 | 77 (64%) | 121 | 0.5938 | 35 (70%) | 50 | 75 (63%) | 119 | 0.3853 |
Smoking status | Â | 169 | Â | 48 | Â | 121 | Â | Â | 50 | Â | 119 | Â |
 Current or former smoker | 147 (87%) |  | 42 (87%) |  | 105 (87%) |  | 1.000 | 45 (90%) |  | 102 (85.7%) |  |  |
 Never smoker | 22 (13%) |  | 6 (13%) |  | 16 (13%) |  | 5 (10%) |  | 17 (14.3%) |  | 0.4498 | |
Performance status OMS | Â | 167 | Â | 47 | Â | 120 | Â | Â | 48 | Â | 119 | Â |
 0–1 | 134 (80%) |  | 33 (70%) |  | 101 (84%) |  | 0.0417 | 39 (81.3%) |  | 95 (79.3%) |  |  |
 2 | 33 (20%) |  | 14 (30%) |  | 19 (16%) |  | 9 (18.2%) |  | 24 (20.2%) |  | 0.8350 | |
Pathological characteristics | ||||||||||||
Histologic subtype | Â | 141 | Â | 46 | Â | 95 | Â | Â | 44 | Â | 97 | Â |
 Adenocarcinoma | 87 (62%) |  | 26 (57%) |  | 61 (64%) |  | 0.0813 | 29 (65.9%) |  | 58 (59.8%) |  |  |
 Squamous cell carcinoma | 37 (26%) |  | 17 (37%) |  | 20 (21%) |  | 11 (25%) |  | 26 (26.8%) |  |  | |
 other | 17 (12%) |  | 3 (6%) |  | 14 (15%) |  | 4 (9.1%) |  | 13 (13.4%) |  | 0.7091 | |
KRAS mutation | 19 (26%) | 74 | 5 (20%) | 25 | 14 (29%) | 49 | 0.5758 | 4 (15.4%) | 26 | 15 (31.3%) | 48 | 0.1358 |
EGFR mutation | 11 (14%) | 79 | 4 (15%) | 26 | 7 (13%)) | 53 | 1.0000 | 4 (14.3%) | 28 | 7 (13.7%) | 51 | 1.000 |
Stage | Â | 169 | Â | 48 | 20 (21%) | 121 | Â | Â | 50 | Â | 119 | Â |
 Local/loco-regional | 86 (51%) |  | 21 (44%) |  | 65 (54%) |  | 0.2424 | 27 (54%) |  | 59 (49.6%) |  | 0.5998 |
 Advanced | 83 (49%) |  | 27 (56%) |  | 56 (46%) |  | 23 (46%) |  | 60 (50.4%) |  | ||