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Table 2 The management and outcome of the relapse patients

From: Gestational trophoblastic neoplasia with extrauterine metastasis but lacked uterine primary lesions: a single center experience and literature review

Patients No

Relapse

Symptoms

Signs

Pretreatment hCG(IU/L)

Interval times after hCG negative (months)

Surgery

Pathological diagnosis

Treatment

6

1

None

Persistent right lung mass

20.6

3

VATS

CC with pulmonary metastasis

3 cycles of EMA-CO

8

1

None

Left ovary abnormality

180.9

5 + 

LUSO

CC

5 cycles of TP

10

1

Epilepsy, convulsions

Brain mass

10.9

3 + 

Gamma knife

CC with brain metastasis

Weekly Albumin Paclitaxel combined with PD-1 immunotherapy (Tirelizumab) for 5 cycles, Tirelizumab maintenance therapy

  1. HCG, Human chorionic gonadotropin, IU/L, International units per liter; VATS, Video-assisted thoracoscopic surgery; LUSO, Laparoscopic unilateral salpingo-oophorectomy; CC, Choriocarcinoma; EMA-CO, Etoposide, Methotrexate, Actinomycin-D/Cyclophosphamide, Vincristine; TP, Paclitaxel, Cisplatin