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Fig. 1 | BMC Cancer

Fig. 1

From: Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer

Fig. 1

NF-κB Activation in MnNP-Treated Polarized NGL-BMDMs. BMDMs isolated from NGL reporter mice were polarized to M1 (IFN-γ + LPS) or M2 (IL-4, 24 or 48 hours) or left unpolarized (M0) and examined for luminescent readout. The M2-polarized BMDMs were also treated with MnNPs for 24 hours before measuring luminescence. For the 24 hour-polarized M2 BMDMs, the Scr- and IκBα-MnNP treatments both increased NF-κB activation, but this effect was more pronounced in the 48-hour IL-4-treated BMDMs, especially with the IκBα-MnNP (n = 3, *p < 0.05 **p < 0.001 ##p < 0.001)

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