MTHFD2 is a potential oncogene for its strong association with poor prognosis and high level of immune infiltrates in urothelial carcinomas of bladder

Table 3 Correlation analysis between MTHFD2 expression and immune checkpoint molecule expression

Gene_name	Immune cells	Rho (Spearman)	p value (Spearman)
MTHFD2	Th2 cells	0.647	< 0.001
MTHFD2	Th1 cells	0.457	< 0.001
MTHFD2	Macrophages	0.450	< 0.001
MTHFD2	NK CD56bright cells	-0.394	< 0.001
MTHFD2	aDC	0.341	< 0.001
MTHFD2	Tgd	0.341	< 0.001
MTHFD2	NK CD56dim cells	0.298	< 0.001
MTHFD2	Neutrophils	0.242	< 0.001
MTHFD2	TReg	0.239	< 0.001
MTHFD2	Tem	0.216	< 0.001
MTHFD2	T cells	0.213	< 0.001
MTHFD2	Cytotoxic cells	0.198	< 0.001
MTHFD2	B cells	0.195	< 0.001
MTHFD2	T helper cells	0.187	< 0.001
MTHFD2	TFH	0.187	< 0.001
MTHFD2	Th17 cells	−0.169	< 0.001
MTHFD2	Eosinophils	0.159	0.001
MTHFD2	CD8 T cells	0.113	0.022
MTHFD2	pDC	−0.108	0.028
MTHFD2	Tcm	0.108	0.027
MTHFD2	NK cells	0.087	0.078
MTHFD2	Mast cells	−0.082	0.095
MTHFD2	iDC	0.056	0.254
MTHFD2	DC	0.054	0.273

ISSN: 1471-2407