Table 2 Univariate and multivariate Cox regression analysis on disease-specific survival
Characteristics | Total(N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
Age | 399 | ||||
< =70 | 226 | Reference | |||
> 70 | 173 | 1.026 (0.718–1.466) | 0.888 | ||
Gender | 399 | ||||
Female | 103 | Reference | |||
Male | 296 | 0.849 (0.576–1.251) | 0.408 | ||
Subtype | 394 | ||||
Papillary | 129 | Reference | |||
Non-Papillary | 265 | 1.734 (1.115–2.695) | 0.015 | 1.182 (0.701–1.993) | 0.530 |
Lymphovascular invasion | 274 | ||||
No | 127 | Reference | |||
Yes | 147 | 3.048 (1.894–4.905) | < 0.001 | 2.971 (1.836–4.810) | < 0.001 |
Histologic grade | 396 | ||||
Low Grade | 21 | Reference | |||
High Grade | 375 | 2.170 (0.535–8.807) | 0.278 | ||
MTHFD2 | 399 | ||||
Low | 203 | Reference | |||
High | 196 | 1.673 (1.168–2.397) | 0.005 | 1.598 (1.022–2.499) | 0.040 |