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Fig. 7 | BMC Cancer

Fig. 7

From: MTHFD2 is a potential oncogene for its strong association with poor prognosis and high level of immune infiltrates in urothelial carcinomas of bladder

Fig. 7

Experimental verification of the oncogenic role of MTHFD2 gene. A, B Knock-down of MTHFD2 by two different siRNAs in two BLCA cell lines. Significance was calculated by. One-way ANOVA *, P < 0.05; **, P < 0.01. C, D The OD value at different time points. Significance was calculated by Two-way repeated measures ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001. E, F FACS (Fluorescence-activated Cell Sorting) of control and si-MTHFD2 cells. Higher fraction in G1 phase represents a less actively dividing state of cells which means less likely to promote oncogenesis

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BMC Cancer

ISSN: 1471-2407

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