Table 5 Impact of different genotypes on over all treatment outcomes
Treatment outcome | Genotype | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CYP1A1 | GSTP1 | GSTM1/GSTT1 combined genotype | |||||||||||
AA (a) | AG (b) | GG (c) | P-value (a vs b vs c) | Ile/Ile (a) | Ile/Val (b) | Val/Val (c) | P-value (a vs b vs c) | WT (a) | M ā (b) | T ā (c) | M ā/Tā (d) | P-value (a vs b vs c vs d) | |
Responders (nā=ā66) | 45 | 6 | 15 | 0.05 | 42 | 21 | 3 | 0.001 | 18 | 27 | 15 | 6 | 0.032 |
Partial Responders (nā=ā21) | 9 | 9 | 3 | 0.001 | 9 | 12 | 0 | 0.034 | 15 | 6 | 0 | 0 | 0.001 |
Non-Responders (nā=ā12) | 9 | 0 | 3 | 0.295 | 0 | 3 | 9 | 0.001 | 3 | 3 | 6 | 0 | 0.068 |