Table 4 Association of Hematological and Molecular response with respect to genes polymorphism in CML patients
Responses | Genotype | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CYP1A1 | GSTP1 | GSTM1/GSTT1 combined genotype | ||||||||||||
AA (a) | AG (b) | GG (c) | P-value (a vs b vs c) | Ile/Ile (a) | Ile/Val (b) | Val/Val (c) | P-value (a vs b vs c) | WT (a) | Mā (b) | Tā (c) | Mā/Tā (d) | P-value (a vs b vs c vs d) | ||
HR(nā=ā33) | CHR (nā=ā21) | 9 | 9 | 3 | 0.029 | 9 | 12 | 0 | 0.001 | 15 | 6 | 0 | 0 | 0.001 |
PHR(nā=ā12) | 9 | 0 | 3 | 0.1 | 0 | 3 | 9 | 0.001 | 3 | 3 | 6 | 0 | 0.001 | |
MR (nā=ā66) | MMR (nā=ā21) | 12 | 6 | 3 | 0.139 | 15 | 6 | 0 | 0.045 | 3 | 9 | 6 | 3 | 0.045 |
DMR (nā=ā42) | 33 | 0 | 12 | 0.001 | 27 | 15 | 3 | 0.184 | 15 | 18 | 9 | 3 | 0.893 | |
NMR (nā=ā33) | Ā | 18 | 9 | 6 | 0.06 | 9 | 15 | 9 | 0.001 | 18 | 9 | 6 | 0 | 0.032 |