Table 4 Characteristics of different skin ADRs
Skin ADRs | Mean score (x ± s) | Incidence (%) |  ≥ 3 Level Incidence (%) | Manifestation | Average time of occurrence | Location | Concomitant symptoms |
|---|---|---|---|---|---|---|---|
Rash | 2.27 ± 1.68 | 75 | 30.1 | Papule; Macula; Pustule | 21 days | Face (87%); Back and chest (69%); Lower limbs (38%); Abdomen (26%) | Itch; Pain; Skin burning; Skin tightness |
Hand-foot syndrome | 2.02 ± 0.82 | 53.4 | 18.6 | Skin redness; Pain; Swelling; Numbness | 32 days | Palms and soles | Increased skin sensitivity; Skin peeling, blisters, bleeding, chapping, and excessive keratosis |
Xerosis | 1.94 ± 0.79 | 41.6 | 11.5 | The skin becomes thin, shriveled, blackened, unresponsive; Skin wrinkles and skin aging | 42 days | Limbs | Skin cracks; Pain; Itch; Blooding; Desquamation |
Pruritus | 2.02 ± 1.40 | 26.7 | 8.9 | Itch; Dry | 53 days | Systemic or local | Edema; Papules; Lichenification; Sclerosis, Exudation; Crusting |
Nail change | 1.40 ± 0.49 | 15.2 | 0 | Granuloma around nails | 49 days | Nails and tissues around nails | Pain; Suppuration; Erythema; Swelling; Lateral nail fissure |
Nail loss | 1.39 ± 0.49 | 7.8 | 0 | The nail bed is separated from the deck | 38 days | Nails | Paronychia; Infection; Nail falling off; Nail lesions |
Hair loss | 1.56 ± 0.50 | 17.6 | 0 | Hair loss; Hair curly, thin and fragile | 33 days | Head; Eye; Face | Eyelashes are thick, long and curly; Facial hairiness |