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Fig. 6 | BMC Cancer

Fig. 6

From: DAB2IP down-regulates HSP90AA1 to inhibit the malignant biological behaviors of colorectal cancer

Fig. 6

DAB2IP overexpression reduces the expression of HSP90AA1 and hinders the progression of colorectal cancer in vivo. a Tumor images of DAB2IP-overexpression and control nude mice (n = 4/group). b Bodyweight of the DAB2IP-overexpression and control groups. The body weight was measured every other day. c Tumor volumes of the DAB2IP-overexpression and control groups. The tumors were measured every 2 days. d HSP90AA1, SRP9, p-ASK1, p-JNK, BAX, BCL-2 expression in xenograft tumors transfected with DAB2IP plasmids or vector by Western blotting. e Ki-67 staining and immunohistochemical analysis of HSP90AA1 and apoptosis proteins BAX, BCL-2 (200 x) in xenograft tumors transfected with DAB2IP plasmids or vector. For each treatment, 3 independent fields from different biopsies were executed. *P < 0.05; **P < 0.01; ***P < 0.001

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