Fig. 5
From: Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer
Disruption of the TRIB3-AKT interaction suppressed NSCLC progression. A, apoptosis of integrin αvβ3 negative A549/PC-9 treated with PBS, Pep2–Ae (20 μg/ml), Cis (1 μg/ml) and combination. B, apoptosis of integrin αvβ3 negative A549/PC-9 treated with PBS, Pep2–Ae (20 μg/ml), PTX (2 μg/ml) and combination. C, apoptosis of integrin αvβ3 positive A549/PC-9 treated with PBS, Pep2–Ae (20 μg/ml), Cis (1 μg/ml) and combination. D, apoptosis of integrin αvβ3 positive A549/PC-9 treated with PBS, Pep2–Ae (20 μg/ml), PTX (2 μg/ml) and combination. E, the tumor volumes of A549 bearing mice treated with PBS Pep2–Ae, Cis and combination. F, the overall survival of A549 bearing mice treated with PBS Pep2–Ae, Cis and combination. G, the tumor volumes of A549 bearing mice treated with PBS Pep2–Ae, PTX and combination. H, the overall survival of A549 bearing mice treated with PBS Pep2–Ae, PTX and combination. n.s means no significant difference, * means p < 0.05, ** means p < 0.01