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Fig. 4 | BMC Cancer

Fig. 4

From: Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer

Fig. 4

TRIB3 interacted with AKT1 to up-regulate FOXO1 and SOX2 expression. A, western blotting of FOXO1 and SOX2 in integrin αvβ3 negative A549/PC-9, integrin αvβ3 positive A549/PC-9 treated with PBS, 3CAI (10 nM) and TRIB3 knockdown. B, co-immunoprecipitation of AKT and TRIB3 in integrin αvβ3 negative A549/PC-9, integrin αvβ3 positive A549/PC-9 cells. C, relative cell proliferation of integrin αvβ3 positive A549/PC-9 cells treated with PBS or Pep2–Ae (20 μg/ml). D, colony formation rates of integrin αvβ3 positive A549/PC-9 cells treated with PBS or Pep2–Ae (20 μg/ml). E, relative migrating cell numbers of integrin αvβ3 positive A549/PC-9 cells treated with PBS or Pep2–Ae (20 μg/ml). * means p < 0.05, ** means p < 0.01

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