Fig. 2
From: Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer
Integrin αvβ3 mediated FAK/AKT signals to promote NSCLC progression. A, western blotting of phosphorylated FAK, total FAK, phosphorylated AKT and total AKT in integrin αvβ3 negative A549/PC-9 and integrin αvβ3 positive A549/PC-9 cells. B, relative proliferation of αvβ3 positive A549/PC-9 cells treated with PBS, Y15 (20 nM) and 3CAI (10 nM). C, the colony formation rates of αvβ3 positive A549/PC-9 cells treated with PBS, Y15 (20 nM) and 3CAI (10 nM). D, relative migrating cell numbers of αvβ3 positive A549/PC-9 cells treated with PBS, Y15 (20 nM) and 3CAI (10 nM). E, the overall survival of NSCLC patients divided into high FAK expression group (n = 127) and low FAK expression (n = 375). F, the overall survival of NSCLC patients divided into high AKT expression group (n = 127) and low AKT expression (n = 375). n.s means no significant difference, * means p < 0.05, ** means p < 0.01