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Fig. 1 | BMC Cancer

Fig. 1

From: Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer

Fig. 1

Integrin αvβ3 promoted NSCLC progression in vitro. A, relative cell proliferation of A549/PC-9, integrin αvβ3 negative A549/PC-9 and integrin αvβ3 positive A549/PC-9 cells. B, the colony formation rates of A549/PC-9, integrin αvβ3 negative A549/PC-9 and integrin αvβ3 positive A549/PC-9 cells. C, the tumor volumes of A549, integrin αvβ3 negative A549 and integrin αvβ3 positive A549 bearing mice. D, the tumorigenesis percentages of A549, integrin αvβ3 negative A549 and integrin αvβ3 positive A549 cells in immunodeficient mice. E, relative migrating cell numbers of A549/PC-9, integrin αvβ3 negative A549/PC-9 and integrin αvβ3 positive A549/PC-9 cells. The scale bar is 15 μm. F, the expression of integrin αvβ3 in para-carcinoma tissues (n = 59) and tumor tissues (n = 515) from NSCLC patients. G, the overall survival of NSCLC patients divided into high integrin αvβ3 expression group (n = 127) and low integrin αvβ3 expression (n = 375). n.s means no significant difference, * means p < 0.05, ** means p < 0.01

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