| | |
BMI (continuous, per 1 kg/m2)
|
CMD (reference: no CMD)
|
|---|
| |
n
|
Adjusted for CMD
|
HR (95%-CI)
|
P-value (LR test)
|
Adjusted for BMI
|
HR (95%-CI)
|
p-value (LR test)
|
|---|
|
Colorectal cancer
|
|
All stages
|
1045
|
No
|
1.06 (1.02–1.10)*
| |
No
|
1.25 (0.97–1.61)
| |
| | |
Yes
|
1.06 (1.02–1.09)*
|
0.065
|
Yes
|
1.22 (0.94–1.57)
|
0.002*
|
|
Localised
|
532
|
No
|
1.10 (1.04–1.17)*
| |
No
|
1.73 (1.15–2.59)*
| |
| | |
Yes
|
1.11 (1.04–1.18)*
|
0.031*
|
Yes
|
1.76 (1.17–2.66)*
|
0.002*
|
|
Advanced
|
513
|
No
|
1.03 (0.99–1.08)
| |
No
|
1.17 (0.83–1.64)
| |
| | |
Yes
|
1.03 (0.98–1.07)
|
0.683
|
Yes
|
1.12 (0.80–1.59)
|
0.213
|
|
Breast cancer
|
|
All stages
|
1620
|
No
|
1.04 (1.00–1.08)*
| |
No
|
1.46 (1.01–2.09)*
| |
| | |
Yes
|
1.04 (1.00–1.08)*
|
0.069
|
Yes
|
1.42 (0.99–2.05)
|
0.135
|
|
Localised
|
1032
|
No
|
1.07 (1.01–1.13)*
| |
No
|
1.38 (0.78–2.46)
| |
| | |
Yes
|
1.07 (1.01–1.13)*
|
0.371
|
Yes
|
1.31 (0.74–2.35)
|
0.009*
|
|
Advanced
|
588
|
No
|
1.01 (0.96–1.07)
| |
No
|
1.51 (0.95–2.42)
| |
| | |
Yes
|
1.01 (0.96–1.07)
|
0.103
|
Yes
|
1.51 (0.94–2.41)
|
0.513
|
- Cox proportional regression stratified by sex (for colorectal cancer), age and country and adjusted for smoking, physical activity, alcohol consumption and education
- BMI: Predicted mean body mass index between age 20 and 50, continuous
- CMD: Diagnosis of cardiometabolic diseases including myocardial infraction, stroke or type 2 diabetes
- P-values of likelihood ratio tests (LR test) comparing models that include CMD in addition to BMI with models including only BMI / comparing models that include BMI in addition to CMD with models including only CMD
- *Statistically significant on a significance-level of p < = 0.05
