Table 2 Means and 95% CI for each QoL Questionnaire and the SPPB for each visit stratified by cohort. The p-value for the between subjects effect of cohorts as calculated by the Repeated Measures ANOVA is displayed as well (italics indicate significant differences) as the number of patients needed to achieve 1 - ß > 0.8 according to post-hoc power analysis

SPPB

9.9 (9.4;10.5)

10.2 (9.5;10.8)

6.1 (4.8;7.3)

4.9 (3.7;6.1)

9.8 (8.8;10.7)

8.2 (6.7;9.7)

9.8 (8.8;10.8)

8.8 (6.6;10.4)

8.7 (7.0;10.4)

8.3 (6.4;10.2)

.416

 ~ 120

SF-8

22.1 (19.7;24.4)

19.0 (16.8;21.3)

28.5 (26.3;30.7)

27.5 (24.6;30.4)

19.4 (15.8;23.0)

22.7 (19.9;25.5)

20.7 (17.9;23.6)

21.7 (17.7;25.7)

23.3 (19.0;27.6)

21.0 (16.5;25.5)

C30 questionnaire

 Global Health Status

55.5 (46.5;64.4)

62.9 (55.6;70.2)

34.9 (26.1;43.6)

40.7 (31.4;50.0

64.4 (55.1;73.6)

55.2 (44.9;65.4)

65.4 (54.9;75.9)

54.8 (43.7;65.8)

62.3 (49.8;74.7)

50.0 (37.9;62.1)

.458

 ~ 100

 Physical functioning

79.0 (70.2;87.8)

81.8 (74.7;88.9)

36.3 (24.9;47.7)

25.8 (14.5;37.2)

78.5 (69.8;87.2)

59.3 (47.0;71.6)

79.0 (69.1;88.9)

57.8 (45.5;70.0)

78.8 (68.3;89.3)

55.8 (41.5;70.1)

.018

 ~ 19

 Role functioning

68.1 (56.3;80.0)

76.0 (65.6;86.4)

22.0 (9.8;34.2)

19.7 (4.4;35.0)

67.4 (54.3;80.6)

54.0 (37.1;70.8)

70.8 (56.2;85.4)

46.8 (30.6;63.0)

73.5 (58.2;88.9)

43.9 (27.8;59.9)

.036

 ~ 36

 Emotional functioning

57.8 (47.7;67.9)

58.8 (48.5;69.1)

57.7 (46.2;69.3)

48.2 (35.7;60.7)

70.5 (58.8;82.1)

50.4 (34.4;66.4)

70.4 (58.1;82.8)

58.3 (46.1;70.6)

67.2 (54.4;79.9)

53.5 (37.0;70.0)

.287

 ~ 100

 Cognitive functioning

80.2 (70.7;89.8)

76.0 (67.7;84.3)

64.8 (53.2;76.4)

58.7 (46.1;71.2)

81.8 (71.8;91.9)

71.4 (58.6;84.2)

82.5 (73.2;91.8)

67.5 (56.5;78.4)

73.5 (59.2;87.8)

64.9 (52.2;77.6)

.350

 ~ 100

 Social functioning

68.2 (55.7;80.8)

76.0 (65.9;86.0)

44.9 (30.4;59.3)

43.1 (25.9;60.2)

67.4 (53.6;81.3)

69.0 (53.5;84.5)

70.0 (57.6;82.5)

60.3 (43.5;77.1)

71.6 (56.8;86.3)

53.5 (36.8;70.2)

.653

 ~ 100

 Fatigue

40.0 (30.3;49.7)

37.9 (27.5;48.3)

72.0 (60.7;83.3)

68.9 (57.5;80.3)

38.4 (28.4;48.4)

53.4 (39.0;67.9)

40.0 (28.5;51.5)

62.4 (49.9;75.0)

37.9 (27.7;48.1)

55.0 (40.6;69.3)

.256

 ~ 100

 Nausea and vomiting

15.2 (7.6;22.8)

10.8 (4.6;16.9)

28.4 (16.1;40.7)

16.7 (4.4;28.9)

8.3 (1.3;15.4)

13.5 (1.3;15.4)

9.2 (-0.7;19.1)

11.1 (0.2;22.0)

7.8 (-4.1;19.8)

5.3 (0.9;9.6)

.563

 > 600

 Pain

27.5 (16.7;38.2)

28.9 (17.2;40.6)

56.2 (43.2;69.1)

37.3 (26.1;48.5)

22.7 (10.8;34.6)

33.3 (18.2;48.5)

30.0 (17.8;42.2)

35.7 (21.2;50.2)

24.5 (9.7;39.4)

38.6;26.1;51.1)

.529

 ~ 100

 Dyspnoea

30.3 (18.1;42.5)

22.6 (11.1;33.5)

48.2 (35.4;60.9)

42.7 (28.8;56.5)

33.3 (19.1;47.6)

28.3 (13.9;42.8)

33.3 (19.9;46.7)

36.5 (22.3;50.7)

21.7 (5.8;37.4)

36.8 (20.4;53.3)

.906

 > 1400

 Insomnia

47.1 (33.8;60.3)

36.3 (24.5;48.1)

66.7 (53.6;79.7)

53.3 (37.8;68.9)

37.9 (21.1;54.7)

50.8 (36.8;64.8)

36.7 (21.8;51.6)

50.0 (33.9;66.1)

39.2 (24.1;54.3)

59.7 (41.2;78.1)

.548

 ~ 34

 Appetite loss

35.3 (23.6;47.0)

21.2 (11.0;31.4)

60.5 (48.4;72.6)

40.0 (25.4;54.6)

25.8 (12.2;39.3)

22.2 (7.0;37.4)

23.3 (9.0;37.6)

19.0 (3.7;34.4)

13.7 (1.1;26.3)

18.5 (7.7;29.4)

.037

 > 750

 Constipation

19.6 (8.9;30.3)

17.7 (6.9;28.4)

41.3 (24.8;57.9)

33.3 (17.3;49.3)

21.2 (7.3;35.2)

15.9 (5.2;26.6)

11.7 (1.9;21.5)

11.1 (2.9;19.3)

11.8 (4.0;19.6)

17.5 (3.1;32.0)

.248

 ~ 100

 Diarrhoea

26.0 (15.2;36.9)

32.4 (20.5;44.2)

17.3 (6.6;28.0)

24.0 (8.7;39.3)

10.6 (2.7;18.5)

27.0 (11.6;42.4)

18.3 (7.2;29.4)

34.9 (19.6;50.2)

17.7 (2.7;32.6)

24.6 (7.4;41.8)

.106

 ~ 100

 Financial difficulties

7.3 (0.3;14.3)

9.4 (2.1;16.7)

11.1 (2.6;19.7)

12.5 (2.2;22.8)

22.7 (7.0;38.5)

16.7 (7.8;25.5)

23.3 (9.0;37.6)

28.1 (12.1;44.1)

9.8 (0.5;19.1)

28.1 (12.9;43.3)

.319

 > 750

PAN26 questionnaire

 Pancreatic Pain

25.5 (17.4;33.6

32.3 (22.5;42.2)

50.6 (39.4;61.8)

41.0 (30.7;51.3)

19.7 (12.9;26.5)

31.4 (20.0;42.7)

22.1 (13.4;30.7)

27.9 (20.0;35.8)

19.1 (10.4;27.8)

40.4 (28.3;52.4)

.120

 > 100

 Bloating

30.4 (18.3;42.5)

23.7 (12.7;34.7)

43.6 (31.2;56.0)

32.0 (19.2;44.8)

15.2 (5.8;24.5)

30.2 (17.5;42.8)

23.3 (11.6;35.0)

28.6 (14.1;43.0)

21.7 (9.1;34.0)

35.1 (19.7;50.5)

.961

 > 100

 Digestive Symptoms

32.4 (21.7;43.0)

22.7 (12.7;32.8)

77.6 (65.6;89.6)

80.7 (69.2;92.1)

34.9 (22.3;47.4)

44.4 (30.3;58.6)

29.2 (16.8;41.5)

34.1 (18.9;49.3)

23.5 (9.5;37.6)

35.1 (21.0;49.2)

.962

 > 100

 Taste

15.7 (6.4;24.9)

19.2 (9.3;29.1)

26.7 (12.6;40.8)

32.0 (17.2;46.8)

27.3 (11.4;43.2)

28.6 (12.8;44.4)

25.0 (13.5;36.5)

34.9 (19.0;50.9)

11.8 (0.6;22.9)

31.6 (17.0;46.1)

.276

 > 100

 Indigestion

29.4 (16.8;42.0)

34.3 (21.2;47.5)

55.1 (40.2;70.1)

61.3 (47.4;75.3)

28.8 (16.4;41.2)

42.9 (27.8;57.9)

30.0 (17.6;42.5)

39.7 (25.7;53.7)

19.6 (9.8;29.4)

38.6 (23.4;53.8)

.162

 > 100

 Flatulence

33.3 (22.3;44.4)

29.3 (18.4;40.2)

44.9 (32.4;57.4)

36.0 (21.0;51.1)

36.4 (21.5;51.2)

18.3 (9.5;27.2)

40.0 (26.9;53.1)

36.5 (23.8;49.2)

39.2 (22.2;56.2)

40.4 (23.4;57.4)

.105

 > 100

 Weight loss

32.4 (18.7;46.0)

33.3 (20.3;46.4)

32.0 (17.2;46.8)

28.0 (12.6;43.4)

31.8 (16.6;47.0)

50.0 (30.2;69.8)

35.0 (17.6;52.4)

34.9 (17.2;52.7)

19.6 (7.0;32.2)

40.4 (21.9;58.8)

.718

 > 100

 Weakness in Arms and Legs

21.6 (12.5;30.7)

22.2 (11.7;32.7)

54.7 (40.6;68.7)

60.0 (45.4;74.6)

39.4 (24.7;54.1)

54.0 (38.0;70.0)

33.3 (19.1;47.6)

55.6 (40.4;70.7)

19.6 (4.7;34.5)

52.6 (33.7;71.5)

.051

 > 100

 Dry Mouth

29.4 (19.2 (39.7)

38.4 (28.1;48.7)

68.0 (56.2;79.7)

66.7 (53.6;79.7)

34.9 (20.3;49.4)

42.9 (27.2;58.6)

31.7 (15.6;47.7)

50.8 (34.8;66.8)

29.4 (12.7;46.1)

38.9 (24.7;53.1)

.618

 > 100

 Hepatic Symptoms

28.4 (18.2;38.7)

30.8 (20.6;41.1)

21.2 (11.5;30.8)

19.3 (7.5;31.2)

10.3 (4.2;16.5)

8.3 (-0.1;16.7)

10.8 (1.6;20.1)

7.9 (1.0;14.9)

13.7 (4.3;23.1)

14.0 (4.9;23.1)

.801

 > 100

 Altered Bowel Habits

29.3 (18.3;40.3)

30.2 (19.2;41.2)

15.3 (5.7;24.9)

23.3 (9.2;37.5)

22.0 (10.1;22.8)

31.0 (17.6;44.3)

35.0 (20.4;49.6)

38.9 (25.5;52.3)

28.4 (14.8;42.1)

28.7 (13.6;43.8)

.507

 > 100

 Body Image

22.0 (12.9;31.2)

21.9 (13.0;30.7)

40.0 (28.2;51.8)

29.0 (18.5;39.5)

25.4 (13.1;37.7)

31.0 (17.6;44.3)

29.8 (15.8;43.9)

36.7 (21.9;51.4)

25.5 (14.6;36.4)

35.1 (22.1;48.0)

.475

 > 100

 Trouble with Side Effects

28.0 (17.0;38.9)

29.2 (19.1;39.2)

62.8 (53.7;71.9)

61.1 (48.3;74.0)

45.5 (32.2;58.7)

49.2 (32.6;65.8)

43.9 (29.7;58.0)

54.0 (36.8;71.1)

35.3 (22.2;48.4)

50.0 (33.9;66.1)

.488

 > 100

 Future Worries

78.1 (67.7;88.5)

65.7 (52.2;79.1)

73.1 (61.0;85.1)

66.7 (52.6;80.8)

63.6 (50.1;77.2)

69.8 (53.0;86.7)

55.0 (39.8;70.2)

65.1 (49.8:80.4)

54.9 (39.1;70.7)

73.7 (57.4;89.9)

.733

 > 100

 Planning Activities

40.6 (26.9;54.3)

44.4 (31.2;57.7)

62.8 (46.5;79.2)

68.1 (51.6;84.5)

40.9 (27.4;54.5)

46.0 (28.9;63.2)

28.3 (12.4;44.2)

50.8 (34.2;67.4)

29.4 (14.7;44.1)

49.1 (31.6;66.7)

.180

 > 100

 Satistfaction with Health Care

11.9 (4.0;19.8)

26.6 (14.4;38.7)

12.2 (4.6;19.8)

13.9 (3.5;24.2)

20.0 (6.5;33.5)

25.0 (12.3;37.7)

33.3 (17.1;49.5)

16.7 (4.2;29.2)

27.8 (12.9;42.6)

5.9 (1.1;10.7)

.048

 > 100

 Sexuality

27.5 (16.1;38.9)

14.5 (4.4;24.6)

17.8 (4.1;31.5)

22.2 (5.5;39.0)

24.5 (11.9;37.1)

11.5 (1.5;21.6)

30.2 (18.2;42.2)

7.7 (-1.1;16.5)

25.6 (11.0;40.1)

6.1 (-0.6;12.7)

.474

 > 100