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Fig. 8 | BMC Cancer

Fig. 8

From: LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression

Fig. 8

LINC00022 promoted the development of CRC in vivo. HCT116 cells with stable low expression of LINC00022 or CaCo-2 cells with stable overexpression of LINC00022 were injected subcutaneously into nude mice. (a) Representative images of tumor tissues in nude mice. (b) The volumes were calculated after being injected with LINC00022-silenced cells or -overexpressed cells. (c and d) The mRNA levels of LINC00022, miR-375-3p, and FOXF1 were detected in tumor tissues. (e) Relative protein levels of c-Myc, pro caspase 3, cleaved caspase 3, MMP2, and VEGFA in tumor tissues. (f) Immunohistochemical staining of FOXF1 in tumor tissues. Scale bar = 50 μm. β-actin served as the internal control. Data were presented as mean ± standard deviation (SD). N = 6. *P < 0.05, **P < 0.01, and ***P < 0.001 vs Lv-anti-NC group or Lv-NC group. FOXF1, Forkhead Box F1; MMP2, matrix metalloproteinase 2; VEGFA, vascular endothelial growth factor-A

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BMC Cancer

ISSN: 1471-2407

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