Table 2 Gene association analysis. Top three genes associated with KC and exclusive development of BCCs or SCCs
From: Associations of keratinocyte cancers with snp variants in the sonic hedgehog pathway
KC vs Controls (total n = 795) | |||||
Chromosome | Gene | No of SNPs analysed in gene | Z score | P value | |
9 | PRKACG | protein kinase cAMP-activated catalytic subunit gamma | 4 | 2.2271 | 0.01297 |
3 | GSK3B | glycogen synthase kinase 3 beta | 29 | 1.5958 | 0.05526 |
7 | SHH | sonic hedgehog signaling molecule | 5 | 1.3246 | 0.09266 |
BCCs exclusively vs Controls (total n = 670) | |||||
Chromosome | Gene | No of SNPs analysed in gene | Z score | P value | |
7 | SHH | sonic hedgehog signaling molecule | 5 | 2.5477 | 0.00542 |
3 | GSK3B | glycogen synthase kinase 3 beta | 29 | 1.8958 | 0.02899 |
9 | PRKACG | protein kinase cAMP-activated catalytic subunit gamma | 4 | 1.7328 | 0.01214 |
SCCs exclusively vs Controls (total n = 539) | |||||
Chromosome | Gene | No of SNPs analysed in gene | Z score | P value | |
15 | KIF7 | kinesin family member 7 | 4 | 2.3964 | 0.00828 |
18 | BCL2 | BCL2 apoptosis regulator | 73 | 2.2388 | 0.01258 |
5 | CSNK1G3 | casein kinase 1 gamma 3 | 8 | 2.0339 | 0.02098 |