Drug | Formulation | Administration | Toxicity |
---|---|---|---|
Methotrexate (MTX) | Tablets | Orally, once weekly. | Bone-marrow suppression leading to leucopenia, thrombocytopenia, and anemia. MTX is also hepatotoxic. |
6-mercaptopurine (6MP) | Tablets and liquid formulation | Orally, daily. Doses are to be taken once a day at a regular schedule. | Bone-marrow suppression leading to leucopenia, thrombocytopenia, and anemia. 6MP is also hepatotoxic. The incidence of hepatotoxicity varies considerably and can occur with any dose, but more frequently when a dose of 75 mg/m2 body surface area per day is exceeded, and most frequent in TPMT wild type patients. In general, the incidence and severity of side effects are considered to be dose-related. |
6-thioguanine (6TG) | 5 mg/mL oral suspensiona | Orally, daily. Doses are to be taken once a day at a regular schedule. | Bone-marrow suppression leading to leucopenia, thrombocytopenia, and anemia. 6TG is also hepatotoxic. At doses higher than those used in TEAM (40–60 mg/m2) 6TG has been related to an increased risk of sinusoidal obstruction syndrome and nodular regenerative hyperplasia. |