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Fig. 4 | BMC Cancer

Fig. 4

From: CT-707 overcomes hypoxia-mediated sorafenib resistance in Hepatocellular carcinoma by inhibiting YAP signaling

Fig. 4

CT-707 increase sorafenib-induced apoptosis under hypoxia by suppressing YAP target genes. A The protein levels of YAP, P-YAP and β-actin in SMMC-7721 cell were detected by western blot analysis in the same conditions as Fig. 2 (D). B A proposed model of crosstalk among Hippo signaling, sorafenib and CT-707 response in hypoxia. On the left, hypoxia caused decreased levels of p-YAP (Ser127), denoting the nuclear translocation of YAP under hypoxic microenvironment, which induce sorafenib resistance. On the right, CT-707 overcome the resistance of sorafenib in hypoxia by preventing YAP nuclear translocation. Full-length blots/gels are presented in Supplementary materials Figure 1B-D

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