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Fig. 2 | BMC Cancer

Fig. 2

From: CT-707 overcomes hypoxia-mediated sorafenib resistance in Hepatocellular carcinoma by inhibiting YAP signaling

Fig. 2

Hypoxia-induced sorafenib resistance can be overcome by CT-707 in vitro. A Chemical structures of CT-707. B, C SMMC-7721 cell was treated with sorafenib at serial concentrations and CT-707 at different concentrations (2 μM, 3 μM, 4 μM), and the inhibition ratio was then determined by SRB assays. Data are representative of 3 independent experiments and are expressed as the mean ± SD. The symbols refer to ** P < 0.01 and *** P < 0.001, respectively. D SMMC-7721 cell was treated with sorafenib (10 μM), CT-707(3 μM) or both, and the cell density was observed by optical microscope

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