Table 1 Comparison of demographics and clinical factors between General and Study Cohorts
Variables, no. (%) | General Cohort (n = 727) | Study Cohort (n = 244) | p-value | p16-positive (n = 189) | p16-negative (n = 55) | p-value |
|---|---|---|---|---|---|---|
Age, years (Mean ± SD) | 60.1 ± 10.5 | 57.3 ± 9.4 | < 0.01 | 56.4 ± 9.2 | 60.3 ± 9.5 | < 0.01 |
Sex | 0.53 | 0.21 | ||||
Male | 569 (78.3) | 186 (76.2) | 148 (78.3) | 38 (69.1) | ||
Female | 158 (21.7) | 58 (23.8) | 41 (21.7) | 17 (30.9) | ||
Anatomical sitea | < 0.01 | 0.03 | ||||
Tonsil | 314 (43.2) | 190 (77.9) | 153 (81.0) | 37 (67.3) | ||
Base of tongue | 311 (42.8) | 48 (19.7) | 33 (17.5) | 15 (27.3) | ||
Other oropharynxb | 98 (13.5) | 5 (2.0) | 2 (1.1) | 3 (5.5) | ||
Smoking historyc | 0.22 | < 0.01 | ||||
Never-smoker | 137 (18.8) | 54 (22.1) | 49 (25.9) | 5 (9.1) | ||
Ever-smoker | 590 (81.2) | 186 (76.2) | 137 (72.5) | 49 (89.1) | ||
Primary treatment | 0.37 | 0.22 | ||||
RT | 430 (59.1) | 136 (55.7) | 101 (53.4) | 35 (63.6) | ||
CRT | 297 (40.9) | 108 (44.3) | 88 (46.6) | 20 (36.4) | ||
5-year survival | 0.06 | < 0.01 | ||||
Alive | 451 (62.0) | 168 (68.9) | 142 (75.1) | 26 (47.3) | ||
Died of disease | 168 (23.1) | 53 (21.7) | 36 (19.0) | 17 (30.9) | ||
Died of other cause | 108 (14.9) | 23 (9.4) | 11 (5.8) | 12 (21.8) |