|
Variables, no. (%)
|
General Cohort (n = 727)
|
Study Cohort (n = 244)
|
p-value
|
p16-positive (n = 189)
|
p16-negative (n = 55)
|
p-value
|
|---|
|
Age, years (Mean ± SD)
|
60.1 ± 10.5
|
57.3 ± 9.4
|
< 0.01
|
56.4 ± 9.2
|
60.3 ± 9.5
|
< 0.01
|
|
Sex
| | |
0.53
| | |
0.21
|
|
Male
|
569 (78.3)
|
186 (76.2)
| |
148 (78.3)
|
38 (69.1)
| |
|
Female
|
158 (21.7)
|
58 (23.8)
| |
41 (21.7)
|
17 (30.9)
| |
|
Anatomical sitea
| | |
< 0.01
| | |
0.03
|
|
Tonsil
|
314 (43.2)
|
190 (77.9)
| |
153 (81.0)
|
37 (67.3)
| |
|
Base of tongue
|
311 (42.8)
|
48 (19.7)
| |
33 (17.5)
|
15 (27.3)
| |
|
Other oropharynxb
|
98 (13.5)
|
5 (2.0)
| |
2 (1.1)
|
3 (5.5)
| |
|
Smoking historyc
| | |
0.22
| | |
< 0.01
|
|
Never-smoker
|
137 (18.8)
|
54 (22.1)
| |
49 (25.9)
|
5 (9.1)
| |
|
Ever-smoker
|
590 (81.2)
|
186 (76.2)
| |
137 (72.5)
|
49 (89.1)
| |
|
Primary treatment
| | |
0.37
| | |
0.22
|
|
RT
|
430 (59.1)
|
136 (55.7)
| |
101 (53.4)
|
35 (63.6)
| |
|
CRT
|
297 (40.9)
|
108 (44.3)
| |
88 (46.6)
|
20 (36.4)
| |
|
5-year survival
| | |
0.06
| | |
< 0.01
|
|
Alive
|
451 (62.0)
|
168 (68.9)
| |
142 (75.1)
|
26 (47.3)
| |
|
Died of disease
|
168 (23.1)
|
53 (21.7)
| |
36 (19.0)
|
17 (30.9)
| |
|
Died of other cause
|
108 (14.9)
|
23 (9.4)
| |
11 (5.8)
|
12 (21.8)
| |
- Abbreviations: RT Radiotherapy, CRT Concurrent chemoradiotherapy
- aUnknown primary (n = 5)
- bIncludes: Soft palate (n = 48), Oropharyngeal wall (n = 32), Vallecula (n = 14), Uvula (n = 8), Anterior surface of epiglottis (n = 1)
- cUnknown smoking status (n = 4)
