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Table 2 Characteristics of studies reporting overall survival for endometrial cancer patients with diabetes compared to without

From: Survival outcomes in endometrial cancer patients according to diabetes: a systematic review and meta-analysis

Author,
year and
location
Study Design Study cohort source/ database Endometrial cancer study population Recruitment period Study size Diabetes ascertainment No. of overall deaths Risk estimate reported Outcome ascertainment Follow-up (mean/ median) NOS score
AlHilli[42]
2016
U.S
Single institution-based Mayo Clinic Stage I-IV 1999–2008 516 a NR NR HR Medical records, tumor registry and death certificates 4.3 years for DM, 5.2 years for non-DM (median) 7
Bjornsdottir [56]
2020
Sweden
Population-based Swedish Cancer Registry NR 1998–2012 NR The Swedish National Diabetes Register NR HR The Total Population Register and Swedish Cause of Death Registry 6.6 years (median) 7
Chen[62]
2016
Taiwan
Single institution-based Chang Gung Memorial hospital Stage I-IV 2000–2010 1450 b Hospital admissions 89 HR NR NR 5
Donkers [57]
2021
U.K
Single institution-based Royal Cornwall Hospital Trust
Truro, Cornwall
High grade EC stages I-IV 2006–2017 176 Medical records 96 HR Medical records NR 8
Folsom[18]
2004
U.S
Population-based Iowa women’s health study and SEER cancer registry Stages I-IV 1986–2000 415 Self-reported 93 RR Registry, questionnaires and NDI 6.4 years (median) 6
Gottwald[60]
2011
Poland
Single institution-based N. Copernicus Memorial Provincial Specialist Hospital Endometrioid EC stages I-III 2000–2007 260 NR 49 HR Medical records NR 3
Hein[45]
2020
Germany
Single institution-based University of Erlangen Stages I-IV 1987–2010 287 Patient files or questionnaire 113 HR Clinical cancer registry NR 5
Ko[35]
2014
U.S
Multi-institution-based University of North Carolina hospital and Duke Cancer Institute Stages I-IV 2005- 2010 1411 Medical records NR HR NR NR 4
Kolehmainen [59]
2020
Finland
Single institution-based Obstetrics and Gynaecology, Helsinki University Hospital Stages I-IV 2007–2012 515 Self-reported 160 HR Medical records and death certificates 6.75 years (median) 4
Kusne [55]
2020
U.S
Single institution-based Mayo Clinic Hospital Stages I-IV 2006–2016 96 a Medical records 6 HR Medical records 3.9 years (median) 5
Larouzée[29]
2019
France
Population-based Echantillon Généraliste de Bénéficiaires (EGB) Stage NR 2005–2014 405 EGB database 155 OR EGB database NR 6
Lees [53]
2021
U.S
Population-based Wisconsin Cancer Registry Stages I-IV 2006–2016 745 Structured interview 450 HR National death index 19.9 years (median) 8
Lemánska[61]
2015
Poland
Single institution-based Poznan University of Medical Sciences Stages I-III 2002–2010 107 Medical database NR HR Greater Poland cancer registry NR 5
Liang[46]
2016
U.S
Single institution -based Memorial Sloan Kettering Cancer Centre High grade stage IA 1995- 2012 85 NR 6 HR Medical records 3.9 years (median) 5
Lindemann[17]
2015
Norway
Population-based Health surveys of North Trondelag (HUNT) Stages I-IV NR 337 Self-reported 166 HR Cancer registry 6.7 years (median) 5
Linder[43]
2006
Poland
Single institution -based Maria Sklodowska-Curie Memorial Cancer Centre Stage I-III 1992- 1998 880 NR NR HR NR 8.8 years (median) 6
Nagle[16]
2018
Australia
Population-based Australian National EC Study Stages I-IV 2005–2007 1359 Self-reported 179 HR Medical records and NDI 7.1 years (median) 6
Nicholas[52]
2014
U.S
Single institution -based Tertiary care centre Stages I-IV 1992–2008 490 Medical records and self-report NR HR Physician records, hospital cancer registry and obituary surveillance 4.5 years (median) 5
Olson[21]
2012
U.S
Population-based SEER-Medicare database Stages I-IV 2000- 2005 12,568 Medicare claims 5,123 HR SEER registries 3.5 years (median) 6
Ruterbusch[19]
2014
U.S
Single institution-based Henry Ford
Health System (HFHS) tumor registry
Stages I-IV 1990–2005 627 HFHS, medical records and the MDCSS 320 HR HFHS, medical records and the MDCSS NR 6
Steiner[63]
2007
Germany and Japan
Multi-institution-based University hospital and the University of Hokkaido Stages I-IV 1985–2003 297 Hospital records 75 HR NR 3.7 years (mean) 4
Stevens[32]
2012
U.S
Multi-institution-based Medical centres at the State University of New York and Tumor registry Endometrioid EC stages I-IV 2000–2010 82 Medical records and tumor registry 25 HR Tumor registry, medical records
and the SSI
NR 5
Strele[36]
2018
Latvia
Population-based cohort Centre for Disease Prevention and Control of Latvia (cancer registry) Stages I-IV 2009–2013 1,685 Diabetes register 470 HR Causes of Death database 2.5 years for DM and 2.7 years for non-DM (median) 6
Zanders[58]
2013
Netherlands
Population-based Eindhoven cancer registry Endometrioid EC stages I-III 2000- 2008 1644 Medical records 310 HR Municipal personal records NR 8
  1. aRestricted to matched/propensity score matched EC patients
  2. bIncluded all uterine cancer patients
  3. EC Endometrial cancer, NOS Newcastle Ottawa Scale, DM Diabetes Mellitus, NDI National Death Index, SEER Surveillance, Epidemiology and End results program. MDCSS Metropolitan Detroit Cancer Surveillance System, SSI Social Security Index, NR Not reported, U.S. United States, HR Hazard Ratio, OR Odds Ratio, RR Relative Risk