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Table 3 Logistic regression analysis of factors affecting colposcopic accuracy for detecting HSIL + 

From: Improving colposcopic accuracy for cervical precancer detection: a retrospective multicenter study in China

Factors

Univariate

Multivariate

OR (95%CI)

p value

OR (95%CI)

p value

Age

 < 30

1.00

 

1.00

 

 30–35

0.75 (0.49–1.17)

0.210

0.63 (0.38–1.03)

0.066

 36–45

0.86 (0.56–1.33)

0.505

1.23 (0.75–2.03)

0.420

  > 45

0.58 (0.37–0.91)

0.019

0.37 (0.21–0.64)

 < 0.001

Cytology

 NILM

1.00

 

1.00

 

 ASC-US

1.27 (0.91–1.76)

0.158

2.11 (1.42–3.15)

 < 0.001

 LSIL

1.76 (1.21–2.54)

0.003

2.42 (1.56–3.70)

 < 0.001

 ASC-H

2.59 (1.52–4.41)

 < 0.001

3.41 (1.89–6.17)

 < 0.001

 HSIL + 

12.48 (5.91–26.34)

 < 0.001

28.26 (12.38–64.52)

 < 0.001

HPV status

 Negative

1.00

 

1.00

 

 Non-16/18 hrHPV positive

1.58 (1.11–2.25)

0.011

1.50 (1.01–2.23)

0.045

 HPV16/18 positive

3.95 (2.69–5.80)

 < 0.001

4.45 (2.87–6.90)

 < 0.001

Transformation zone

 TZ1/2

1.00

 

1.00

 

 TZ3

0.47 (0.36–0.61)

 < 0.001

0.45 (0.34–0.62)

 < 0.001

Colposcopist’s skills

 Junior

1.00

 

1.00

 

 Senior

2.43 (1.84–3.20)

 < 0.001

2.24 (1.63–3.07)

 < 0.001

  1. Abbreviations: OR odds ratio, CI confidence interval, NILM no intraepithelial lesion cells and malignant cells, ASC-US atypical squamous cells of unknown significance, LSIL low-grade squamous intraepithelial lesion, ASC-H atypical squamous cells of cannot exclude high-grade squamous intraepithelial lesion, HSIL + high-grade squamous intraepithelial lesions or worse, hrHPV high-risk human papillomavirus, TZ transformation zone