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Table 2 hCD19 CAR-T treatment and outcomes

From: Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy

Variables

No.

(n = 19)

% of

patients

Numbers of patients

Total

CR

Relapse/Death

Grade of CRS

 0

1

5

 1

15

79

 2

2

11

 4

1

5

Neurotoxicity

 No

17

89

 Grade 1

2

11

Treatment response on D30

 CR

13

68

 NR

6

32

Follow-up

CR group

  

13

  

  allo-HCT

11

10

1/1(same case)

  non-HCT

2

0

2/1

NR group

  

6

  

  allo-HCT

3

1

2/1

  non-HCT

3

0

0/3

  1. Abbreviations: CRS Cytokine release syndrome, CR Complete remission, including CR with incomplete blood count recovery, NR No response, allo-HCT Allogeneic hematopoietic cell transplantation