Table 1 Patient characteristics
Characteristics | No.(n = 19) | % of patients |
|---|---|---|
Age (years) | ||
Median | 20 (range 4–49) | |
Children (< 18) | 8 | 42 |
Adults | 11 | 58 |
Sex | ||
Male | 10 | 53 |
Female | 9 | 47 |
Prior allo-HCT | ||
Yes | 10 | 53 |
No | 9 | 47 |
CD22 CAR-T (simultaneously with or after mCD19 CAR-T) | ||
Yes | 11 | 58 |
No | 8 | 42 |
Disease status at enrollment | ||
Isolated BM (blasts 7–98%) | 12 | 63 |
Extramedullary disease (EMD) | 7 | 37 |
CNS | 2 | |
Multiple sites (1 with CNS) | 5 | |
Adverse genetic changes | ||
BCR/ABL | 2 | 11 |
Ph-like (2 with TP53 gene mutation) | 7 | 37 |
Interval time between last mCD19 | ||
CAR-T and hCD19 CAR-T (months) | ||
< 6 | 6 | 32 |
6–12 | 4 | 21 |
> 12 | 9 | 47 |