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Table 2 The multivariate analysis of prognostic factors associated with PFS and OS

From: Four cycles of R-CHOP followed by two applications of rituximab based on negative interim PET/CT: an analysis of a prospective trial

 

PFS

OS

 

Event / N

3y-PFS%

(95%CI)

HR

(95%CI)

P

Event / N

3y-OS%

(95%CI)

HR

(95% CI)

P

Age (years)

  

0.64 (0.1–19.71)

0.79

  

0.32 (0.01–199.21)

0.79

≤60

10/103

90.3 (87.4–96.0)

  

7/103

93.2 (88.3–98.1)

  

> 60

2/26

90.8 (84.5–97.1)

  

0/26

100 (NA)

  

Extranodal involvement

  

1.03 (0.36–2.98)

0.95

  

0.53 (0.11–2.65)

0.44

No

6/70

91.4 (84.7–98.1)

  

4/70

94.2 (91.4–97.1)

  

Yes

6/59

89.3 (81.3–97.3)

  

3/70

94.9 (92.1–97.8)

  

Ann Arbor Stage

  

2.81 (0.71–10.41)

0.12

  

3.87 (0.45–33.5)

0.22

I

2/56

96.0 (93.2–98.8)

  

1/56

98.1 (96.4–99.8)

  

II

10/73

86.3 (78.5–94.1)

  

6/73

91.8 (88.6–95.0)

  

ECOG PS

  

2.11 (0.36–6.23)

0.18

  

2.2 (0.49–9.93)

0.31

0

6/73

91.7 (85.4–97.9)

  

3/73

95.9 (93.6–98.2)

  

1

6/56

88.7 (80.1–97.3)

  

4/56

92.9 (89.5–96.3)

  

B symptoms

  

1.88 (0.36–9.69)

0.45

  

5.27 (0.81–34.3)

0.08

No

10/120

91.4 (86.3–96.5)

  

5/120

95.8 (94.1–97.6)

  

Present

2/9

77.8 (63.9–91.7)

  

2/9

77.8 (63.9–91.7)

  

LDH level

  

NAa

0.99

  

NAa

0.99

Normal

12/122

89.9 (84.4–96.4)

  

7/122

94.2 (92.1–96.3)

  

Elevated

0/7

100 (NA)

  

0/7

100 (NA)

  

IPI score

  

NAa

0.84

  

NAa

0.82

0–1

12/126

90.3 (85.1–95.6)

  

7/126

94.4 (92.4–96.4)

  

2

0/3

100 (NA)

  

0/3

100 (NA)

  

interim PET/CT

  

2.4 (0.66–9.03)

0.18

  

3.68 (0.71–19.12)

0.12

Negative

9/115

91.9 (86.8–97.1)

  

5/115

95.6 (93.7–97.5)

  

Positive

3/14

78.6 (67.6–89.6)

  

2/14

85.7 (76.3–95.1)

  
  1. Abbreviations: PFS Progression Free Survival, OS Overall Survival, LDH Lactate Dehydrogenase, IPI International Prognostic Index, NA Not applicable;
  2. * P < 0.05
  3. a Because the sample size is too small, HR can not be calculated