Fig. 6

Drug-Target-PPI network for CRC. Fourteen Drugs approved by FDA for treating CRC (mainly when the cancer metastasize) are used to construct this network; the drug nodes are shown in the center area. The target genes have been found from DrugBank. For each target gene node, four circles are associated with that gene corresponding to four stages I-IV, and are colored based on the log2FC values between a stage and normal (dark blue (log2FC of -1) to white (0) to dark red (log2 FC of 1)). The size of each circle represents the sum of the weights of edges connected to that gene (i.e., gene weights) in each stage. For example, MAPK11 weight is greater in stage I as compared to that in other stages. PPI edges from STRING-db (score threshold ≥ 0.9) are also incorporated in this network by dashed grey-lines between the genes. Some important pathways are also shown. For select functionally important genes, the related functions are listed