Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study

Table 4 ROC analysis of ACAT1/CE/TC/FC in peritoneal fluid, plasma and tumor tissue

Source	Analyte (n)	ROC	p-value
Peritoneal Fluid	ACAT1 Protein (n = 47)	0.9444	< 0.0001
	Cholesterol ester (n = 24)	0.9125	0.0011
	Total cholesterol (n = 24)	0.9015	0.0011
	Free cholesterol (n = 24)	0.8788	0.0021
Tissue	ACAT1 Protein (n = 33)	0.9398	< 0.0001
Tissue	ACAT1 mRNA (n = 25)	0.9805	< 0.0001
Plasma	ACAT1 Protein (n = 29)	0.621	NS
	Cholesterol ester (n = 26)	0.534	NS
	Total cholesterol (n = 26)	0.504	NS
	Free cholesterol (n = 26)	0.500	NS

ACAT1 acyl-CoA cholesterol acyltransferase, CE cholesterol ester, TC total cholesterol, FC free cholesterol, NS Non significant, n number of samples

ISSN: 1471-2407