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Fig. 3 | BMC Cancer

Fig. 3

From: Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study

Fig. 3

Lipid profiles in biological samples. Samples were collected from non-malignant (subjects with normal ovaries [Normal] and benign pelvic masses [BPM]) and ovarian cancer (EOC) patients. Box plots show medians (interquartile ranges) and whiskers (the minimum and maximum values). “d” indicates statistically significant difference compared to EOC *: p < .05; **: p < .001; ***: p < .0001. (a-c) Cholesteryl ester (CE), total cholesterol (TC) and free cholesterol (FC) levels in peritoneal fluid (non-malignant, n = 9; normal, n = 5; BPM n = 4; EOC, n = 15). Experiments were performed in triplicate. (d-e) Thin layer chromatography analysis of lipids in tissue samples. (d) Lipids were extracted from tissue samples, resolved by thin layer chromatography, stained and quantified. Lipids were identified FS or CE by comparison to standards. Representative results of normal ovary, BPM, EOC stage I and EOC stage III tissue lipids are shown. (e) Percent of CE to TC (non-malignant, n = 7; normal, n = 2; BPM n = 5; EOC, n = 12). Asterisks indicate statistically significant difference between non-malignant and EOC cohorts (*: p < .05)

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BMC Cancer

ISSN: 1471-2407

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