Clinicopathological and ultrasound features as risk stratification predictors of clinical and pathological nodal status in papillary thyroid carcinoma: a study of 748 patients

Table 3 Risk factors for cN1 in patients with PTC

Variable	Univariate analysis			Multivariate analysis
Variable	OR	95% CI	p	OR	95% CI	p
Age (reference: ≤ 40	—	—	—
> 40 and ≤ 55	0.60	0.34 ~ 1.05	0.07
> 55	0.70	0.28 ~ 1.76	0.44
Gender (Female vs. Male)	0.65	0.33 ~ 1.27	0.20
HT (yes vs. no)	0.73	0.28 ~ 1.89	0.52
Nodular goiters (yes vs. no)	1.53	0.90 ~ 2.61	0.12
Multifocality (yes vs. no)	1.49	0.80 ~ 2.75	0.21
Bilaterality (yes vs. no)	1.01	0.58 ~ 1.73	0.98
Primary tumor size (reference: ≤ 1 cm)	—	—	—
> 1and ≤ 2 cm	4.48	2.42 ~ 8.30	< 0.001*	1.71	0.80 ~ 3.62	0.17
> 2 cm	16.96	7.70 ~ 37.33	< 0.001*	5.05	1.88 ~ 13.55	0.01*
Capsule contact (yes vs. no)	19.08	4.62 ~ 78.76	< 0.001*	5.77	1.27 ~ 26.30	0.02*
ETE (yes vs. no)	14.64	7.07 ~ 30.32	< 0.001*	4.20	1.78 ~ 9.92	0.01*
E_max	1.03	1.01 ~ 1.05	0.001*
E_mean	1.02	0.99 ~ 1.04	0.08
ER	3.27	1.99 ~ 5.35	< 0.001*
Central LNM (yes vs. no)	18.25	8.80 ~ 37.88	< 0.001*	5.18	2.22 ~ 12.06	< 0.001*
Number of pN1 (> 5 vs. ≤ 5)	45.43	21.52 ~ 95.92	< 0.001*	9.52	4.04 ~ 22.43	< 0.001*

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