Diagnostic value of circulating genetically abnormal cells to support computed tomography for benign and malignant pulmonary nodules

Table 2 Comparison in different diagnostic methods

Models	AUC	95%CI	N	Youden index	SE	SP	PPV	NPV
PNAIDS	0.696	0.587-0.806	93	0.351	76.3%	58.8%	76.3%	58.8%
CAC counts	0.779	0.683-0.875	93	0.410	76.3%	64.7%	78.9%	61.1%
Mayo model	0.468	0.342-0.593	93	0.083	84.7%	23.5%	65.8%	47.1%
CEA	0.543	0.398-0.688	66	0.244	47.5%	76.9%	76.0%	48.8%
CYFRA21–1	0.519	0.375-0.663	66	0.181	45.0%	73.1%	72.0%	46.3%
NSE	0.494	0.352-0.636	66	0.125	12.5%	100.0%	100.0%	42.6%
TM	0.524	0.376-0.673	66	0.131	90.0%	23.1%	64.3%	60.0%
Model 1	0.654	0.522-0.785	66	0.337	37.5%	96.2%	93.8%	50.0%
Model 2	0.847	0.769-0.924	93	0.551	61.0%	94.1%	94.7%	58.2%
Model 3	0.841	0.744-0.939	66	0.548	62.5%	92.3%	92.6%	61.5%

N Number of samples, SE Sensitivity, SP Specificity, PPV Positive predictive value, NPV Negative predictive value; TM, the combination of CEA, CYFRA21–1 and NSE; Model 1, PNAIDS combined TM; Model 2, PNAIDS combined CAC; Model 3, PNAIDS combined CAC and TM

ISSN: 1471-2407