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Table 1 Melatonin Binding Sites MT1 and MT2 and known locations for protein exprssion

From: The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature

Binding site Other Names Gene location Central locations for protein expression Peripheral locations for protein expression
MT1 Mel1a or ML1A Chromosome 4 (4q35.1) SCN, amygdala, hippocampus, hypothalamus, nucleus accumbens, substantia nigra, and the cerebellum. The cardiovascular system and immune system as well as the testes, ovaries, skin, liver, gallbladder, kidney, adrenal cortex, placenta, breast, pancreas, and spleen.
MT2 Mel1b or ML1B Chromosome 11 (11q21-q22) Retina, SCN, hippocampus, and cerebral cortex. Blood vessels, testes, kidneys, gastrointestinal tract, mammary glands, adipose tissue, and the skin.