Table 1 Melatonin Binding Sites MT1 and MT2 and known locations for protein exprssion
From: The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature
Binding site | Other Names | Gene location | Central locations for protein expression | Peripheral locations for protein expression |
|---|---|---|---|---|
MT1 | Mel1a or ML1A | Chromosome 4 (4q35.1) | SCN, amygdala, hippocampus, hypothalamus, nucleus accumbens, substantia nigra, and the cerebellum. | The cardiovascular system and immune system as well as the testes, ovaries, skin, liver, gallbladder, kidney, adrenal cortex, placenta, breast, pancreas, and spleen. |
MT2 | Mel1b or ML1B | Chromosome 11 (11q21-q22) | Retina, SCN, hippocampus, and cerebral cortex. | Blood vessels, testes, kidneys, gastrointestinal tract, mammary glands, adipose tissue, and the skin. |