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Table 6 Real-time fluorescence quantitative PCR detection of target gene mRNA expression in each tissue (copies/μl RNA x ± S)

From: Observation of the cervical microbiome in the progression of cervical intraepithelial neoplasia

Gene Name

Normal group (n = 38)

CIN group (n = 52)

Cervical Cancer Group (n = 30)

P value

ATM

22.07 ± 65.65

7.70 ± 25.82

38.48 ± 104.85

P = 0.074*

P = 0.294**

P = 0.005***

ABCG2

24.33 ± 41.26

36.08 ± 81.64

3.91 ± 7.22

P = 0.133*

P = 0.018**

P = 0.000***

PCNA

59.18 ± 108.64

37.00 ± 74.94

351.83 ± 960.67

P = 0.967*

P = 0.033**

P = 0.004***

OGG1

20.18 ± 35.81

6.64 ± 16.88

10.08 ± 15.49

P = 0.003*

P = 0.786**

P = 0.008***

TDG

5.18 ± 8.83

4.22 ± 9.09

17.63 ± 26.20

P = 0.053*

P = 0.031**

P = 0.000***

LIG1

0.20 ± 0.26

0.38 ± 1.08

0.70 ± 1.88

P = 0.546*

P = 0.010**

P = 0.001***

HMGB1

21,235.07 ± 38,403.32

33,052.50 ± 54,685.92

95,839.75 ± 190,013.59

P = 0.039*

P = 0.001**

P = 0.038***

XRCC1

1.08 ± 1.97

2.27 ± 5.24

1.76 ± 4.74

P = 0.270*

P = 0.776**

P = 0.476***

SMUG1

57.19 ± 238.93

85.84 ± 189.57

100.67 ± 301.45

P = 0.452*

P = 0.466**

P = 0.900***

FEN1

30.05 ± 41.93

24.29 ± 43.85

79.65 ± 193.15

P = 0.508*

P = 0.970**

P = 0.637***

  1. * represents the comparison between the normal group and the CIN group, ** represents the comparison between the normal group and the cervical cancer group, and *** represents the comparison between the CIN group and the cervical cancer group