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Table 2 Univariate and multivariate analysis of prognosis for ICC after radical resection

From: Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study

  OS RFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95%CI) P HR (95%CI) P HR (95%CI) P HR (95%CI) P
Sex
 Female vs Male 0.935(0.721 ~ 1.212) 0.610    0.891(0.717 ~ 1.109) 0.302   
Age (year)
  > 55 vs ≤ 55 1.242(0.955 ~ 1.615) 0.105    1.046(0.838 ~ 1.305) 0.693   
Obstructive jaundice
 Yes vs No 1.172(0.872 ~ 2.150) 0.175    1.090(0.729 ~ 1.628) 0.675   
Etiology
 HBV-ICC vs Con-ICC 0.801(0.567 ~ 1.130) 0.206 0.862(0.608 ~ 1.223) 0.405 1.143(0.873 ~ 1.498) 0.331   
 Stone-ICC vs Con-ICC 2.185(1.597 ~ 2.989)  < 0.001 2.009(1.447 ~ 2.789)  < 0.001 1.563(1.181 ~ 2.068) 0.002   
AFP (ng/ml)
  > 7.0 vs ≤ 7.0 1.137(0.834 ~ 1.550) 0.416    1.041(0.804 ~ 1.348) 0.761   
CEA (ng/ml)
  > 5.0 vs ≤ 5.0 1.439(1.076 ~ 1.923) 0.014    1.348(1.054 ~ 1.725) 0.017   
CA19-9(U/ml)
  > 39.0 vs ≤ 39.0 1.378(1.056 ~ 1.798) 0.018    1.370(1.097 ~ 1.711) 0.006 1.252(1.010 ~ 1.568) 0.030
CA125(U/ml)
  > 35.0 vs ≤ 35.0 1.604(1.218 ~ 2.111) 0.001    1.308(1.046 ~ 1.635) 0.019   
Child–Pugh Grade
 Grade B vs A 1.150(0.709 ~ 1.866) 0.570    1.006(0.662 ~ 1.526) 0.979   
Type of resection
 Minor hepatectomy vs Wedge resection 1.718(1.284 ~ 2.297)  < 0.001 1.157(1.127 ~ 2.043) 0.006 1.684(1.318 ~ 2.151)  < 0.001 1.515(1.183 ~ 1.941) 0.001
 Major hepatectomy vs Wedge resection 1.962(1.344 ~ 2.864)  < 0.001 1.405(1.149 ~ 2.080) 0.019 1.829(1.324 ~ 2.528)  < 0.001 1.733(1.245 ~ 2.411) 0.001
Lymphadenectomy
 Yes vs No 0.909(0.697 ~ 1.185) 0.479    1.048(0.837 ~ 1.312) 0.683   
Tumor differentiation
 Moderate vs Well 1.318(0.739 ~ 2.352) 0.350    1.002(0.644 ~ 1.560) 0.993   
 Poor vs Well 2.243(1.228 ~ 4.095) 0.009    1.597(1.108 ~ 2.302) 0.012   
Tumor location
 Right vs Left 0.689(0.518 ~ 1.129) 0.069    0.890(0.704 ~ 1.127) 0.334   
 Left and right vs Left 0.857(0.556 ~ 1.321) 0.485    0.976(0.685 ~ 1.391) 0.895   
Morphologic grape
 Periductal infiltrating vs Mass-forming 0.871(0.559 ~ 1.358) 0.543    0.997(0.700 ~ 1.420) 0.986   
 Intraductal growth vs Mass-forming 0.825(0.502 ~ 1.357) 0.448    0.789(0.530 ~ 1.174) 0.789   
Tumor size (cm)
  > 5.0 vs ≤ 5.0 1.517(1.148 ~ 2.003) 0.003 1.352(1.034 ~ 1.797) 0.028 1.164(0.936 ~ 1.149) 0.173   
Major vascular invasion
 Yes vs No 1.716(1.249 ~ 2.357) 0.001    1.606(1.217 ~ 2.121) 0.001   
Microvascular invasion
 Yes vs No 1.506(1.009 ~ 2.248) 0.045    1.748(1.388 ~ 2.202)  < 0.001 1.788(1.400 ~ 2.257)  < 0.001
Perineural invasion
 Yes vs No 2.068(1.421 ~ 3.008)  < 0.001    1.331(0.964 ~ 1.838) 0.083   
Liver capsule involvement
 Yes vs No 1.136(0.857 ~ 1.507) 0.375    1.262(0.894 ~ 1.783) 0.186   
AJCC 8th edition T stage
 T2 vs T1a/T1b 1.317(0.947 ~ 1.831) 0.101    1.164(0.885 ~ 1.532) 0.277   
 T3/T4 vs T1a/T1b 1.559(1.080 ~ 2.250) 0.018    1.713(1.273 ~ 2.305)  < 0.001   
AJCC 8th edition N stage
 N1 vs N0 1.949(1.459 ~ 2.603)  < 0.001 1.791(1.334 ~ 2.406)  < 0.001 1.648(1.289 ~ 2.106)  < 0.001 1.378(1.070 ~ 1.776) 0.013
AJCC 8th edition TNM stage
 II vs IA/IB 1.362(0.947 ~ 1.961) 0.096    1.258(0.907 ~ 1.746) 0.170   
 IIIA/IIIB/IV vs IA/IB 1.521(1.138 ~ 2.033) 0.005    1.732(1.365 ~ 2.198)  < 0.001   
Adjuvant chemotherapy
 Yes vs No 0.685(0.520 ~ 0.902) 0.007 0.632(0.469 ~ 0.851) 0.003 0.715(0.568 ~ 0.901) 0.005 0.655(0.517 ~ 0.831)  < 0.001