Table 1 Comparison of clinicopathological characteristic for ICC with different etiological subtypes after radical resection
|  | ICC with different etiological subtypes | χ2 | P value | ||
|---|---|---|---|---|---|
Con-ICC (%) | HBV-ICC (%) | Stone-ICC (%) | |||
Sex | |||||
 Male | 127(48.7) | 63(61.8) | 33(38.8) | 10.073 | 0.006 |
 Female | 134(51.3) | 39(38.2) | 52(61.2) | ||
Age (year) | |||||
  ≤ 55 | 110(42.1) | 51(50.0) | 26(30.6) | 7.226 | 0.027 |
  > 55 | 151(57.9) | 51(50.0) | 59(69.4 | ||
Obstructive jaundice | |||||
 No | 246(94.3) | 100(98.0) | 69(81.2) | 21.723 |  < 0.001 |
 Yes | 15(5.7) | 2(2.0) | 16(18.8) | ||
AFP (ng/ml) | |||||
  ≤ 7.0 | 203(78.8) | 77(75.5) | 63(74.1) | 0.563 | 0.755 |
  > 7.0 | 58(22.2) | 25(24.5) | 22(25.9) | ||
CEA (ng/ml) | |||||
  ≤ 5.0 | 200(76.6) | 77(75.5) | 60(70.6) | 1.260 | 0.533 |
  > 5.0 | 61(23.4) | 25(24.5) | 25(29.4) | ||
CA19-9(U/ml) | |||||
  ≤ 39.0 | 121(46.1) | 48(47.1) | 25(29.4) | 8.260 | 0.016 |
  > 39.0 | 140(53.6) | 54(52.9) | 60(70.6) | ||
CA125(U/ml) | |||||
  ≤ 35.0 | 161(61.7) | 59(57.8) | 51(60.0) | 0.464 | 0.793 |
  > 35.0 | 100(38.3) | 43(42.2) | 34(40.0) | ||
Child–Pugh Grade | |||||
 Grade A | 247(94.6) | 99(97.1) | 74(87.1) | 8.750 | 0.013 |
 Grade B | 14(5.4) | 3(2.9) | 11(12.9) | ||
Type of resection | |||||
 Wedge resection | 108(41.4) | 49(48.0) | 28(32.9) | 8.722 | 0.068 |
 Minor hepatectomy | 109(41.8) | 43(42.2) | 36(42.4) | ||
 Major hepatectomy | 44(16.9) | 10(9.8) | 21(24.7) | ||
Tumor differentiation | |||||
 Well | 17(6.5) | 4(3.9) | 7(8.2) | 3.227 | 0.521 |
 Moderate | 164(62.8) | 59(57.8) | 49(57.6) | ||
 Poor | 80(30.7) | 39(38.2) | 29(34.1) | ||
Tumor location | |||||
 Left | 128(49.0) | 36(35.3) | 56(65.9) | 18.423 | 0.001 |
 Right | 99(37.9) | 53(52.0) | 23(27.1) | ||
 Left and right | 34(13.0) | 13(12.7) | 6(7.1) | ||
Morphologic grape | |||||
 Mass-forming | 221(84.7) | 88(86.3) | 51(60.0) | 28.811 |  < 0.001 |
 Periductal infiltrating | 24(9.2) | 8(7.8) | 17(20.0) | ||
 Intraductal growth | 16(6.1) | 6(5.9) | 17(20.0) | ||
Tumor size (cm) | |||||
  ≤ 5.0 | 135(51.7) | 52(51.0) | 50(58.8) | 1.493 | 0.474 |
  > 5.0 | 126(48.3) | 50(49.0) | 35(41.2) | ||
Major vascular invasion | |||||
 No | 217(83.1) | 91(89.2) | 69(81.2) | 2.725 | 0.256 |
 Yes | 44(16.9) | 11(10.8) | 16(18.8) | ||
Microvascular invasion | |||||
 No | 235(90.0) | 87(85.3) | 71(83.5) | 3.246 | 0.197 |
 Yes | 26(10.0) | 15(14.7) | 14(16.5) | ||
Perineural invasion | |||||
 No | 223(85.4) | 96(94.1) | 66(77.6) | 10.535 | 0.005 |
 Yes | 38(14.6) | 6(5.9) | 19(22.4) | ||
Liver capsule involvement | |||||
 No | 180(69.0) | 64(62.7) | 69(81.2) | 7.722 | 0.021 |
 Yes | 81(31.0) | 38(37.3) | 16(18.8) | ||
AJCC 8th edition T stage | |||||
 T1a/T1b | 63(24.1) | 27(26.5) | 26(30.6) | 3.817 | 0.431 |
 T2 | 132(50.6) | 45(44.1) | 43(50.6) | ||
 T3/T4 | 66(25.3) | 30(29.4) | 16(18.8) | ||
AJCC 8th edition N stage | |||||
 N0 | 193(73.9) | 82(80.4) | 61(71.8) | 2.211 | 0.031 |
 N1 | 68(26.1) | 20(19.6) | 24(28.2) | ||
AJCC 8th edition TNM stage | |||||
 IA/IB | 119(45.6) | 42(41.2) | 45(52.9) | 3.540 | 0.472 |
 II | 40(15.3) | 20(19.6) | 10(11.8) | ||
 IIIA/IIIB/IV | 102(39.1) | 40(39.2) | 30(35.3) | ||