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Table 1 Comparison of clinicopathological characteristic for ICC with different etiological subtypes after radical resection

From: Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study

  ICC with different etiological subtypes χ2 P value
Con-ICC (%) HBV-ICC (%) Stone-ICC (%)
Sex
 Male 127(48.7) 63(61.8) 33(38.8) 10.073 0.006
 Female 134(51.3) 39(38.2) 52(61.2)
Age (year)
  ≤ 55 110(42.1) 51(50.0) 26(30.6) 7.226 0.027
  > 55 151(57.9) 51(50.0) 59(69.4
Obstructive jaundice
 No 246(94.3) 100(98.0) 69(81.2) 21.723  < 0.001
 Yes 15(5.7) 2(2.0) 16(18.8)
AFP (ng/ml)
  ≤ 7.0 203(78.8) 77(75.5) 63(74.1) 0.563 0.755
  > 7.0 58(22.2) 25(24.5) 22(25.9)
CEA (ng/ml)
  ≤ 5.0 200(76.6) 77(75.5) 60(70.6) 1.260 0.533
  > 5.0 61(23.4) 25(24.5) 25(29.4)
CA19-9(U/ml)
  ≤ 39.0 121(46.1) 48(47.1) 25(29.4) 8.260 0.016
  > 39.0 140(53.6) 54(52.9) 60(70.6)
CA125(U/ml)
  ≤ 35.0 161(61.7) 59(57.8) 51(60.0) 0.464 0.793
  > 35.0 100(38.3) 43(42.2) 34(40.0)
Child–Pugh Grade
 Grade A 247(94.6) 99(97.1) 74(87.1) 8.750 0.013
 Grade B 14(5.4) 3(2.9) 11(12.9)
Type of resection
 Wedge resection 108(41.4) 49(48.0) 28(32.9) 8.722 0.068
 Minor hepatectomy 109(41.8) 43(42.2) 36(42.4)
 Major hepatectomy 44(16.9) 10(9.8) 21(24.7)
Tumor differentiation
 Well 17(6.5) 4(3.9) 7(8.2) 3.227 0.521
 Moderate 164(62.8) 59(57.8) 49(57.6)
 Poor 80(30.7) 39(38.2) 29(34.1)
Tumor location
 Left 128(49.0) 36(35.3) 56(65.9) 18.423 0.001
 Right 99(37.9) 53(52.0) 23(27.1)
 Left and right 34(13.0) 13(12.7) 6(7.1)
Morphologic grape
 Mass-forming 221(84.7) 88(86.3) 51(60.0) 28.811  < 0.001
 Periductal infiltrating 24(9.2) 8(7.8) 17(20.0)
 Intraductal growth 16(6.1) 6(5.9) 17(20.0)
Tumor size (cm)
  ≤ 5.0 135(51.7) 52(51.0) 50(58.8) 1.493 0.474
  > 5.0 126(48.3) 50(49.0) 35(41.2)
Major vascular invasion
 No 217(83.1) 91(89.2) 69(81.2) 2.725 0.256
 Yes 44(16.9) 11(10.8) 16(18.8)
Microvascular invasion
 No 235(90.0) 87(85.3) 71(83.5) 3.246 0.197
 Yes 26(10.0) 15(14.7) 14(16.5)
Perineural invasion
 No 223(85.4) 96(94.1) 66(77.6) 10.535 0.005
 Yes 38(14.6) 6(5.9) 19(22.4)
Liver capsule involvement
 No 180(69.0) 64(62.7) 69(81.2) 7.722 0.021
 Yes 81(31.0) 38(37.3) 16(18.8)
AJCC 8th edition T stage
 T1a/T1b 63(24.1) 27(26.5) 26(30.6) 3.817 0.431
 T2 132(50.6) 45(44.1) 43(50.6)
 T3/T4 66(25.3) 30(29.4) 16(18.8)
AJCC 8th edition N stage
 N0 193(73.9) 82(80.4) 61(71.8) 2.211 0.031
 N1 68(26.1) 20(19.6) 24(28.2)
AJCC 8th edition TNM stage
 IA/IB 119(45.6) 42(41.2) 45(52.9) 3.540 0.472
 II 40(15.3) 20(19.6) 10(11.8)
 IIIA/IIIB/IV 102(39.1) 40(39.2) 30(35.3)