Clinicopathological features of HER2 positive metastatic colorectal cancer and survival analysis of anti-HER2 treatment

Table 6 Univariate survival analyses of patients according to various clinicopathological variables

Variable	Median OS(M)	P	Variable	Median OS(M)	P
Age, Years			Tumor Differentiation
< 54	48.2	0.923	Poor	31.2	0.193
≥ 54	48.9		Medium	48.2
Sex			Well	not reached
Male	31.2	0.02	primary lesion resection
Female	48.9		Yes	48.2	0.001
Primary site			No	10.2
Left semi-colon and rectum	48.2	0.006	Metastasectomy
Right colon	9.4		Yes	32.3	0.415
Number of metastatic organs			No	48.2
single	49.9	0.485	Status of KRAS NRAS BRAF
≥ 2	41.9		Mutant	32.2	0.085
Metastatic patterns			WT	48.2
synchronous	32.2	0.012	Adjuvant chemotherapy
Metachronous	49.9		Yes	48.9	0.227
Therapy Line			No	48.2
First-line	20	0.223	local therapies
Second-Line	41.9		Yes	41.9	0.347
Third- or later-line	48.9		No	50.7

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