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Table 3 Relationship between clinical parameters and lymphocyte subsets in low-risk group before therapy (T1) (n=149)

From: Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma

Parameters

Age

p

Sex

p

Smoking

p

Drinking

p

Family history of cancer

p

Histology

p

T classification

p

N classification

p

UICC stage

p

<50 vs ≥50

Male vs Female

Yes vs No

Yes vs No

Yes vs No

K vs NK

pT1-2 vs pT3-4

pN0-1 vs pN2-3

I-II vs III-IV

CD3+ %

72.35±9.17

67.26±10.74

.011

68.94±10.35

70.84±10.50

.336

68.13±10.80

70.69±9.87

.133

68.07±9.95

69.94±10.55

.324

68.49±9.11

69.92±11.04

.423

67.18±9.76

69.70±10.46

.347

68.70±9.88

69.54±10.51

.726

68.75±11.67

69.64±9.95

.744

68.20±8.81

69.51±10.52

.301

CD3+ count

1.19±0.40

1.15±0.41

.666

1.20±0.41

1.07±0.39

.101

1.22±0.41

1.11±0.40

.107

1.17±0.41

1.16±0.41

.894

1.21±0.41

1.14±0.40

.310

1.22±0.40

1.16±0.41

.569

1.22±0.37

1.16±0.42

.910

1.05±0.43

1.21±0.39

.216

1.15±0.44

1.17±0.41

.406

CD3+CD4+ %

38.26±8.58

38.26±8.49

.647

38.47±8.85

37.61±7.45

.594

38.73±8.31

37.80±8.72

.508

38.84±7.60

38.03±8.86

.605

38.37±9.08

38.20±8.22

.908

37.58±7.66

38.35±8.63

.726

38.77±7.99

38.17±8.62

.990

38.35±9.11

38.23±8.33

.886

39.61±8.67

38.15±8.51

.941

CD3+CD4+ count

0.63±0.25

0.65±0.25

.466

0.67±0.26

0.57±0.21

.029

0.69±0.25

0.60±0.25

.020

0.68±0.27

0.63±0.24

.347

0.68±0.27

0.62±0.24

.160

0.69±0.25

0.64±0.25

.466

0.69±0.24

0.64±0.25

.799

0.59±0.26

0.66±0.25

.423

0.68±0.31

0.64±0.25

.656

CD3+CD8+ %

28.22±8.19

24.79±7.58

.011

25.55±7.69

28.32±8.65

.068

24.99±7.89

27.48±7.97

.057

25.30±7.44

26.61±8.21

.370

25.20±8.42

26.82±7.74

.240

24.58±6.39

26.46±8.18

.364

25.84±7.66

26.31±8.09

.526

25.13±7.51

26.62±8.16

.606

23.35±6.09

26.47±8.10

.158

CD3+CD8+ count

0.46±0.20

0.43±0.20

.255

0.44±0.20

0.43±0.20

.759

0.45±0.21

0.43±0.19

.539

0.43±0.17

0.45±0.21

.662

0.44±0.21

0.44±0.20

.916

0.45±0.19

0.44±0.20

.847

0.46±0.19

0.44±0.21

.822

0.38±0.19

0.46±0.20

.168

0.39±0.15

0.45±0.21

.277

CD4/CD8 ratio

1.52±0.71

1.72±0.74

.055

1.68±0.76

1.49±0.63

.157

1.73±0.77

1.54±0.68

.099

1.68±0.62

1.62±0.77

.644

1.77±0.91

1.56±0.61

.097

1.65±0.57

1.63±0.75

.939

1.68±0.79

1.63±0.72

.734

1.68±0.65

1.62±0.76

.845

1.84±0.66

1.62±0.74

.149

CD3-CD56+ %

15.49±8.13

19.7±9.93

.027

18.37±9.56

16.57±8.96

.315

19.28±9.55

16.58±9.14

.080

19.40±9.44

17.34±9.38

.230

18.79±8.42

17.44±9.93

.407

20.22±10.83

17.63±9.22

.286

19.52±10.57

17.63±9.20

.605

18.92±10.95

17.58±8.86

.228

20.74±11.07

17.7±9.28

.110

CD3-CD56+ count

0.26±0.20

0.33±0.20

.096

0.32±0.21

0.25±0.16

.055

0.35±0.21

0.26±0.18

.010

0.33±0.21

0.29±0.20

.250

0.34±0.21

0.28±0.19

.090

0.39±0.27

0.29±0.19

.054

0.36±0.24

0.29±0.19

.502

0.28±0.18

0.31±0.21

.466

0.35±0.25

0.30±0.20

.792

CD3-CD19+ %

9.17±4.11

9.93±4.31

.215

9.80±4.37

9.03±3.77

.341

9.49±4.68

9.73±3.76

.724

9.95±4.75

9.48±4.02

.542

9.62±3.87

9.6±4.43

.983

10.07±4.20

9.55±4.24

.634

9.60±4.12

9.61±4.26

.138

9.43±4.38

9.67±4.19

.283

9.19±4.03

9.64±4.25

.059

CD3-CD19+ count

0.15±0.09

0.17±0.10

.158

0.17±0.10

0.13±0.08

.034

0.17±0.11

0.15±0.08

.198

0.17±0.11

0.16±0.09

.437

0.17±0.09

0.16±0.10

.475

0.19±0.12

0.16±0.09

.144

0.17±0.09

0.16±0.10

.406

0.14±0.09

0.17±0.10

.159

0.15±0.08

0.16±0.10

.146

CD3+CD56+ %

2.94±1.58

2.66±2.18

.528

2.81±2.09

2.67±1.47

.693

2.79±2.29

2.77±1.56

.939

2.94±2.77

2.72±1.52

.538

2.49±1.35

2.93±2.20

.188

2.95±1.49

2.76±2.00

.695

2.46±1.27

2.84±2.05

.132

2.73±1.40

2.79±2.11

.921

2.61±1.17

2.79±2.00

.247

CD3+CD56+ count

0.05±0.03

0.05±0.04

.837

0.05±0.04

0.04±0.03

.209

0.05±0.04

0.04±0.03

.184

0.05±0.05

0.04±0.03

.296

0.04±0.02

0.05±0.04

.352

0.06±0.03

0.05±0.04

.234

0.04±0.03

0.05±0.04

.280

0.04±0.02

0.05±0.04

.716

0.04±0.03

0.05±0.04

.230

CD4+CD45RA+ %

11.85±6.06

10.79±5.67

.706

11.31±5.99

11.02±5.45

.793

11.26±5.85

11.22±5.87

.967

11.15±5.38

11.28±6.04

.908

11.84±6.07

10.91±5.72

.356

11.92±5.59

11.15±5.89

.614

10.63±4.90

11.35±6.01

.951

11.57±6.60

11.13±5.59

.815

10.11±4.68

11.33±5.93

.723

CD4+CD45RA+ count

0.19±0.11

0.18±0.12

.898

0.20±0.12

0.16±0.10

.156

0.20±0.12

0.18±0.11

.229

0.20±0.12

0.18±0.11

.590

0.21±0.13

0.18±0.11

.091

0.20±0.07

0.19±0.12

.603

0.19±0.12

0.19±0.12

.976

0.18±0.12

0.19±0.11

.874

0.17±0.11

0.19±0.12

.742

CD4+CD45RA- %

21.37±6.04

22.36±5.00

.276

21.78±5.62

22.42±5.02

.537

22.11±4.98

21.78±5.93

.712

22.60±4.17

21.68±5.90

.358

21.49±5.43

22.19±5.50

.459

20.66±5.22

22.11±5.49

.308

22.71±5.79

21.80±5.42

.598

20.49±4.65

22.44±5.65

.100

24.25±6.11

21.76±5.39

.135

CD4+CD45RA- count

0.35±0.17

0.38±0.15

.326

0.38±0.16

0.34±0.13

.144

0.40±0.16

0.34±0.14

.019

0.40±0.17

0.36±0.15

.227

0.38±0.16

0.36±0.15

.476

0.39±0.19

0.37±0.15

.613

0.40±0.14

0.37±0.16

.646

0.31±0.14

0.39±0.16

.025

0.41±0.19

0.37±0.15

.476

CD4+CD45RA+/CD4+CD45RA- ratio

0.60±0.39

0.50±0.29

.303

0.55±0.36

0.52±0.28

.561

0.54±0.37

0.55±0.31

.957

0.50±0.24

0.56±0.37

.301

0.59±0.41

0.52±0.29

.186

0.62±0.36

0.53±0.34

.302

0.50±0.26

0.55±0.35

.769

0.62±0.46

0.52±0.28

.242

0.42±0.19

0.55±0.35

.309

CD4+CD45RO+ %

21.17±6.26

22.28±5.19

.209

21.69±5.84

22.16±5.19

.511

22.02±5.20

21.60±6.13

.689

22.41±4.34

21.57±6.12

.329

21.17±5.57

20.46±5.42

.422

20.46±5.42

21.98±5.70

.321

22.63±5.98

21.66±5.62

.567

20.42±4.82

22.28±5.88

.176

24.15±6.48

21.62±5.58

.130

CD4+CD45RO+ count

0.35±0.17

0.38±0.15

.301

0.38±0.17

0.33±0.13

.129

0.40±0.17

0.34±0.14

.017

0.39±0.17

0.36±0.16

.205

0.38±0.16

0.36±0.16

.445

0.39±0.19

0.37±0.16

.605

0.40±0.15

0.36±0.16

.633

0.31±0.14

0.39±0.16

.036

0.41±0.20

0.37±0.16

.452

CD8+CD38+ %

5.80±2.81

6.70±4.22

.149

6.42±4.05

6.01±2.42

.556

6.55±4.47

6.09±2.78

.451

5.90±3.26

6.49±3.87

.385

6.50±3.02

6.22±4.05

.666

7.50±3.94

6.17±3.67

.164

6.29±2.83

6.32±3.86

1.000

6.51±4.92

6.25±3.22

.846

6.19±2.32

6.33±3.80

.934

CD8+CD38+ count

0.10±0.07

0.11±0.08

.273

0.11±0.08

0.09±0.04

.096

0.12±0.09

0.09±0.06

.045

0.11±0.08

0.11±0.07

.946

0.11±0.07

0.10±0.08

.374

0.14±0.09

0.10±0.07

.090

0.11±0.07

0.11±0.08

.952

0.10±0.08

0.11±0.07

.843

0.10±0.05

0.11±0.08

.794

WBC count

6.66±1.80

6.51±2.02

.948

6.88±1.92

5.67±1.66

<.001

6.86±1.94

6.29±1.88

.068

6.50±2.06

6.60±1.88

.781

6.62±1.58

6.55±2.10

.845

6.91±1.96

6.53±1.93

.446

6.27±1.77

6.63±1.96

.812

6.01±1.60

6.77±2.00

.169

5.77±1.64

6.64±1.94

.282

Neutrophil count

4.42±1.44

4.22±1.68

.790

4.50±1.61

3.70±1.34

.007

4.42±1.60

4.19±1.56

.366

4.18±1.61

4.35±1.57

.563

4.19±1.23

4.37±1.75

.512

4.33±1.64

4.30±1.58

.943

3.86±1.30

4.38±1.62

.432

3.97±1.37

4.42±1.64

.422

3.46±1.01

4.37±1.60

.152

NLR

2.90±1.16

2.64±1.17

.399

2.77±1.15

2.68±1.25

.695

2.62±1.07

2.88±1.25

.173

2.55±0.91

2.83±1.25

.202

2.59±1.14

2.83±1.18

.230

2.61±1.30

2.77±1.16

.610

2.25±0.72

2.84±1.21

.145

2.80±1.03

2.73±1.22

.881

2.19±0.63

2.79±1.19

.261

Monocyte count

0.61±0.31

0.59±0.31

.600

0.64±0.32

0.46±0.23

.002

0.67±0.30

0.53±0.30

.003

0.60±0.27

0.60±0.32

.881

0.65±0.34

0.57±0.29

.100

0.74±0.48

0.58±0.28

.053

0.63±0.27

0.59±0.32

.947

0.52±0.14

0.63±0.35

.297

0.63±0.26

0.60±0.31

.966

LMR

3.06±1.58

3.15±1.39

.645

2.83±1.13

3.96±1.98

<.001

2.78±1.10

3.44±1.70

.005

3.01±1.28

3.15±1.54

.583

3.09±1.20

3.13±1.60

.870

3.02±1.11

3.12±1.51

.785

3.22±1.36

3.09±1.49

.710

3.09±1.11

3.12±1.57

.111

2.81±0.89

3.14±1.50

.201

Platelet count

243.29±73.56

224.67±61.31

.067

237.46±66.58

217.68±67.61

.121

234.78±63.22

230.33±71.19

.687

238.14±71.64

230.35±65.54

.526

235.74±62.18

230.78±70.01

.668

219.00±63.99

234.29±67.59

.379

234.30±64.34

232.22±67.90

.107

224.18±58.13

235.41±69.99

.731

227.00±65.20

232.99±67.52

.181

PLR

162.06±65.31

141.9±54.91

.074

147.51±58.01

159.24±66.30

.338

141.73±56.83

158.99±62.46

.593

151.10±67.92

150.15±57.17

.499

145.11±53.48

153.35±63.62

.279

129.38±46.85

153.13±61.28

.328

139.81±47.86

152.36±62.11

.228

160.71±57.39

146.90±60.92

.465

146.68±55.69

150.72±60.68

.125

SII

707.31±336.55

592.26±302.43

.033

655.44±313.2

596.91±345.40

.306

626.69±319.88

654.94±324.23

.080

612.37±298.22

652.11±330.59

.932

602.41±285.09

662.16±339.19

.425

568.91±307.30

650.18±323.01

.126

543.90±267.39

658.61±328.02

.092

628.82±267.55

645.04±338.75

.906

498.00±196.81

652.30±326.99

.317

ALB

44.68±5.52

43.06±5.17

.085

43.91±5.88

43.23±3.38

.504

43.60±5.04

43.89±5.70

.741

43.59±3.12

43.80±6.03

.831

43.16±3.67

44.06±6.10

.327

41.51±4.92

44.03±5.37

.068

44.24±3.07

43.65±5.69

.960

45.33±8.15

43.20±3.90

.090

43.83±1.98

43.74±5.55

.974

LDH

196.13±49.84 

204.29±49.44

.248

199.19±44.13

205.84±63.84

.481

198.43±38.58

203.21±58.66

.558

199.93±39.08 

201.20±53.33

.889

202.04±48.18

200.18±50.61

.827

208.24±73.29

199.89±46

.516

185.35±31.72

203.67±51.81

.248

188.37±36.37

205.11±52.85

.270

184.64±34.78

202.13±50.47

.620

  1. Abbreviations: K keratinizing, NK non-keratinizing, NLR neutrophil count/Lymphocyte count, LMR lymphocyte count/monocyte count, PLR Platelet count/Lymphocyte count, SII Platelet count×Neutrophil count/Lymphocyte count, ALB albumin, LDH lactate dehydrogenase
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