The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series

Table 4 Univariate and multivariate survival analysis performed by Cox proportional hazard regression with factors from univariate analysis p > 0.05. The metric variables were dichotomized according to the median

	HR (95% CI)	p-value
univariate
postoperative KPS, ≥ 70	4.25 (1.25–14.45)	0.021
postoperative MRC-NPS, ≥ 4	4.25 (1.25–14.45)	0.021
radiation therapy brain	0.25 (0.08–0.80)	0.019
radiation therapy modality, whole brain	5.40 (1.27–22.88)	0.022
preoperative tumor load, > 14.59 cm³	1.66 (0.66–4.19)	0.283
postoperative tumor load, > 0 cm³	1.03 (0.41–2.60)	0.948
multivariate
postoperative KPS, ≥ 70	0.16 (0.02–1.18)	0.072
postoperative MRC-NPS, ≥ 4	a
radiation therapy brain	a
radiation therapy modality, whole brain	4.36 (0.95–20.02)	0.059

HR Hazard ratio, KPS Karnofsky performance status, MRC-NPS Medical Research Council Neurological Performance Score. a degree of freedom reduced due to constant or linear dependent covariates, constant or linearly dependent covariates postoperative MRC-NPS ≥ 4, postoperative KPS ≥ 70

ISSN: 1471-2407