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Table 4 Univariate and multivariate survival analysis performed by Cox proportional hazard regression with factors from univariate analysis p >  0.05. The metric variables were dichotomized according to the median

From: The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series

  HR (95% CI) p-value
univariate
 postoperative KPS, ≥ 70 4.25 (1.25–14.45) 0.021
 postoperative MRC-NPS, ≥ 4 4.25 (1.25–14.45) 0.021
 radiation therapy brain 0.25 (0.08–0.80) 0.019
 radiation therapy modality, whole brain 5.40 (1.27–22.88) 0.022
 preoperative tumor load, >  14.59 cm3 1.66 (0.66–4.19) 0.283
 postoperative tumor load, >  0 cm3 1.03 (0.41–2.60) 0.948
multivariate
 postoperative KPS, ≥ 70 0.16 (0.02–1.18) 0.072
 postoperative MRC-NPS, ≥ 4 a  
 radiation therapy brain a  
 radiation therapy modality, whole brain 4.36 (0.95–20.02) 0.059
  1. HR Hazard ratio, KPS Karnofsky performance status, MRC-NPS Medical Research Council Neurological Performance Score. a degree of freedom reduced due to constant or linear dependent covariates, constant or linearly dependent covariates postoperative MRC-NPS ≥ 4, postoperative KPS ≥ 70