Fig. 1

illustrates the dynamic framework of the different work packages during the concept development phase. Abbreviations: MHRT Moderately-hypofractionated radiotherapy, SBRT Stereotactic body radiotherapy, PCa Prostate cancer, RCT Randomized controlled trial, CDP Concept development phase, IGRT Image-guided radiotherapy, PIC Patient informed consent, mpMRI Multiparametric magnetic resonance imaging, PSMA PET/CT Prostate-specific membrane antigen positron emissions-tomography and computed tomography