Table 4 Multivariable cox proportional hazards analysis of factors predictive of survival

Tumor Grade

1.134(0.960–1.339)

0.138

1.274(0.962–1.687)

0.091

 High

 Median

 Low

T Stage

1.507(1.298–1.748)

 < 0.001

1.220(0.967–1.538)

0.094

 T1

ref

 T2

1.404(0.891–2.210)

0.143

 T3

2.409(1.662–3.492)

 < 0.001

 T4a

2.784(1.618–4.789)

 < 0.001

N Stage

1.464(1.297–1.653)

 < 0.001

1.499(1.218–1.845)

 < 0.001

 N0

ref

ref

 N1

1.484(1.100–2.001)

0.010

1.194(0.719–1.982)

0.493

 N2

2.300(1.681–3.146)

 < 0.001

3.335(2.064–5.389)

 < 0.001

 N3

2.950(1.905–4.457)

 < 0.001

2.608(1.166–5.835)

0.020

TNM Classification

1.011(0.744–1.374)

0.944

0.810(0.477–1.375)

0.435

 I

 II

 III/IV

Anastomotic Leak

1.472(1.057–2.050)

0.022

1.804(1.053–3.094)

0.032

 No

ref

ref

 Yes

1.508(1.081–2.104)

0.016

2.042(1.206–3.460)

0.008

Pulmonary Infection

1.122(0.856–1.471)

0.405

 No

 Yes