Table 1 Colorectal cancer cell lines used for the study

TNM stage

?

III

?

II/III

II

III

 CIN

+

–

–

+

+

+

 MSI

–

+

+

–

–

–

 CIMP

–

+

+

+

–

–

 CMS subtype

2

N/A

1

3

N/A

N/A

 Proteomic subtype

A

B

B

D

E

B

 KRAS

–

G13D

G13D

–

G12V

G12V

 BRAF

–

–

–

V600E

–

–

 PIK3CA

–

E545K; D549N

H1047R

P449T

–

–

 TP53

E204X

S241F

–

R273H

R273H; P309S

R273H; P309S

 Radio-sensitivity (LD50)

4.3 Gy

2.9 Gy

1.7 Gy

4.6 Gy

2.4 Gy

2.7 Gy

 5-FU-sensitivity (IC₅₀)

2.1 μM

9.3 μM

4.5 μM

2.7 μM

2.4 μM

6.7 μM