Table 2 Relationship between gene mutation of SDHB, protein expression of SDHB and Nrf2, and FDG-PET
Pheochromocytoma (n = 21) / Paraganglioma (n = 8) | SDHB gene mutation | P value | SDHB expression | P value | Nrf2 | P value | SUVmax (mean ± S.D) | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
No (n = 25) | Yes (n = 4) | Lower (Non to Low) (n = 5) | Higher (Moderate to High) (n = 24) | Lower (Non to Low) (n = 21) | HIgher (Moderate to High) (n = 8) | ||||||
PASS < 4 or GAPP with well differentiation (n = 18) | 18 | 0 |  < 0.0001 | 0 | 18 |  < 0.0001 | 17 | 1 | 0.0011 | 4.8 ± 0.7 | 0.0026 |
PASS ≥ 4 or GAPP with moderately to poorly differentiation (n = 11) | 7 | 4 | 5 | 6 | 4 | 7 | 13.2 ± 9.0 | ||||
Metastasis | |||||||||||
  No:M0 (n = 25) | 25 | 0 |  < 0.0001 | 1 | 24 |  < 0.0001 | 21 | 4 | 0.0029 | 5.9 ± 2.4 | 0.0019 |
  Yes:M1 (n = 4) | 0 | 4 | 4 | 0 | 0 | 4 | 20.5 ± 8.9 | ||||
SDHB gene mutation | |||||||||||
  No (n = 25) |  |  |  | 1 | 24 |  < 0.0001 | 21 | 4 | 0.0005 | 5.9 ± 2.4 | 0.0019 |
  Yes (n = 4) |  |  |  | 4 | 0 | 0 | 4 | 20.5 ± 8.9 | |||
SDHB expression | |||||||||||
  Negative (Non—Low) (n = 5) |  |  |  |  |  |  | 1 | 4 | 0.0047 | 5.3 ± 1.0 | 0.0018 |
  Positive (Moderate—High) (n = 24) |  |  |  |  |  |  | 20 | 4 | 18.9 ± 8.4 | ||
Nrf2 expression | |||||||||||
  Negative (Non—Low) (n = 21) |  |  |  |  |  |  |  |  |  | 5.9 ± 2.5 | 0.0039 |
  Positive (Moderate—High) (n = 8) |  |  |  |  |  |  |  |  | 17.8 ± 9.8 | ||