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Fig. 1 | BMC Cancer

Fig. 1

From: Suppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway

Fig. 1

Cell viability assay and colosphere forming assay with αM–treated cancer stem cells. A Mangostin fruit and chemical structure of αM extracted from Garcinia mangostana Linn. B, C Effect of αM on the viability of SW620 and HT29 cells. SW620 and HT29 cells were treated with various concentrations of αM (0, 2.5, 5.0, 10, 20, and 40 μM in SW620 cells, N = 7; 0, 0.25, 0.5, 1.0, 2.0, 4.0, and 8.0 μM in HT29 cells, N = 4) for 72 h. D, E Colosphere-forming assay was performed with various concentrations of αM (0, 1.25, 2.5, 5, and 10 μM in SW620 cells; 0, 0.25, 0.5, 1, and 2 μM in HT29 cells) for 14 days. Based on a size-matched control for each cell line, the number of spheres in SW620 and HT29 cells were counted on day 14. N = 12 Data are expressed as mean ± SD values. *P < 0.05, **P < 0.01, ***P < 0.001

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