Treatment | Cumulative incidence (%, 95 CI) | Incidence density (per 100 persons-year, 95% CI) | |||
---|---|---|---|---|---|
≤3 years | 3-4 years | 4-5 years | >5 years | ||
Total patients | |||||
ETV | 4.08 (0.88-9.03) | 5.81 (3.52-8.61) | 6.55 (4.84-8.49) | 8.24 (7.34-9.18) | 1.43 (1.14-1.75) |
TDF | 3.16 (1.12-6.14) | 3.65 (2.21-5.42) | 7.12 (5.97-8.37) | NEa | 1.07 (0.74-1.46) |
Other NAs | 10.34 (6.60-14.78) | 11.11 (4.35-20.23) | 13.04 (1.81-30.45) | 12.61 (11.22-14.07) | 2.84 (1.86-4.00) |
Patient with preexisting cirrhosis | |||||
ETV | 5.01 (1.32-10.49) | 10.16 (6.91-13.93) | 11.71 (10.72-12.73) | 14.21 (10.87-17.91) | 2.78 (2.21-3.40) |
TDF | NA | 7.76 (5.46-10.42) | 12.48 (5.86-21.11) | NA | 2.59 (1.51-3.96) |
Other NAs | 10.34 (6.60-14.78) | NA | 21.28 (18.61-24.08) | 24.49 (13.33-37.62) | 4.81 (3.36-6.49) |
Patient without preexisting cirrhosis | |||||
ETV | 0.66 (0.19-1.38) | 1.79 (1.05-2.69) | 2.78 (1.49-4.44) | 3.04 (2.05-4.21) | 0.49 (0.32-0.68) |
TDF | 0.09 (0.02-0.20) | NA | 2.26 (1.17-3.68) | NA | 0.30 (0.06-0.70) |
Other NAs | NA | NA | NA | 4.54 (3.31-5.94) | 0.78 (0.56-1.02) |