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Table 2 The association between clinical characteristics of 425 OPC patients an HPV positive OPC defined by HPV PCR testing and p16 IHC staining

From: Rising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common

 

HPV PCR

p16 IHC

 

Negative

Positive

P value

Negative

Positive

P value

Age (years)

  < 50

104 (72.7)

39 (27.3)

0.45

93 (71.5)

37 (28.5)

0.48

 50–60

113 (72.9)

42 (27.1)

 

100 (69.9)

43 (30.1)

 

  > 60

71 (66.4)

36 (33.6)

 

61 (64.2)

34 (35.8)

 

Gender

 Male

271 (74.3)

94 (25.8)

 < 0.01

241 (71.4)

92 (27.6)

 < 0.01

 Female

17 (42.5)

23 (57.5)

 

13 (37.1)

22 (62.9)

 

Cigarette smoking

 Never

44 (50.6)

43 (49.4)

 < 0.01

36 (48.0)

39 (52.0)

 < 0.01

 Ever

199 (77.1)

9 (22.9)

 

175 (75.1)

58 (24.9)

 

Alcohol drinking

 Never

57 (49.1)

59 (50.9)

 < 0.01

51 (49.0)

53 (51.0)

 < 0.01

 Ever

162 (80.6)

39 (19.4)

 

145 (78.4)

40 (21.6)

 

Betel quid chewing

 Never

92 (54.4)

77 (45.6)

 < 0.01

78 (51.7)

73 (48.3)

 < 0.01

 Ever

128 (85.9)

21 (14.1)

 

119 (86.2)

19 (13.8)

 

T classification

 T1

58 (20.0)

27 (23.0)

 < 0.01

46 (18.1)

32 (28.0)

 < 0.01

 T2

82 (27.8)

50 (42.7)

 

73 (28.7)

39 (34.2)

 

 T3

37 (12.8)

17 (14.5)

 

33 (13.0)

20 (17.5)

 

 T4

76 (26.4)

13 (11.1)

 

68 (26.8)

13 (11.4)

 

N classification

 N0

82 (27.8)

17 (14.5)

 < 0.01

71 (28.0)

17 (14.9)

 < 0.01

 N1

33 (11.4)

9 (7.7)

 

26 (10.2)

10 (8.8)

 

 N2

111 (38.5)

72 (61.5)

 

98 (38.6)

65 (57.0)

 

 N3

27 (9.3)

9 (7.7)

 

25 (9.8)

12 (10.5)

 

Overall stage

 I

32 (11.1)

4 (3.4)

 < 0.01

25 (9.8)

6 (5.2)

0.13

 II

28 (9.7)

9 (7.7)

 

25 (9.8)

8 (7.0)

 

 III

38 (13.1)

10 (8.5)

 

31 (12.2)

11 (9.6)

 

 IV

155 (53.8)

84 (71.8)

 

139 (54.7)

79 (69.3)

 

Location

 Tonsil

131 (59.5)

89 (40.5)

 < 0.01

115 (57.5)

85 (42.5)

 < 0.01

 Tongue base

69 (82.1)

15 (17.9)

 

64 (80.0)

16 (20.0)

 

 Soft palate

66 (91.7)

6 ( 8.3)

 

57 (90.5)

6 (9.5)

 

 Unspecific

22 (75.9)

7 (24.1)

 

18 (72.0)

7 (28.0)

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