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Table 2 The association between clinical characteristics of 425 OPC patients an HPV positive OPC defined by HPV PCR testing and p16 IHC staining

From: Rising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common

  HPV PCR p16 IHC
  Negative Positive P value Negative Positive P value
Age (years)
  < 50 104 (72.7) 39 (27.3) 0.45 93 (71.5) 37 (28.5) 0.48
 50–60 113 (72.9) 42 (27.1)   100 (69.9) 43 (30.1)  
  > 60 71 (66.4) 36 (33.6)   61 (64.2) 34 (35.8)  
Gender
 Male 271 (74.3) 94 (25.8)  < 0.01 241 (71.4) 92 (27.6)  < 0.01
 Female 17 (42.5) 23 (57.5)   13 (37.1) 22 (62.9)  
Cigarette smoking
 Never 44 (50.6) 43 (49.4)  < 0.01 36 (48.0) 39 (52.0)  < 0.01
 Ever 199 (77.1) 9 (22.9)   175 (75.1) 58 (24.9)  
Alcohol drinking
 Never 57 (49.1) 59 (50.9)  < 0.01 51 (49.0) 53 (51.0)  < 0.01
 Ever 162 (80.6) 39 (19.4)   145 (78.4) 40 (21.6)  
Betel quid chewing
 Never 92 (54.4) 77 (45.6)  < 0.01 78 (51.7) 73 (48.3)  < 0.01
 Ever 128 (85.9) 21 (14.1)   119 (86.2) 19 (13.8)  
T classification
 T1 58 (20.0) 27 (23.0)  < 0.01 46 (18.1) 32 (28.0)  < 0.01
 T2 82 (27.8) 50 (42.7)   73 (28.7) 39 (34.2)  
 T3 37 (12.8) 17 (14.5)   33 (13.0) 20 (17.5)  
 T4 76 (26.4) 13 (11.1)   68 (26.8) 13 (11.4)  
N classification
 N0 82 (27.8) 17 (14.5)  < 0.01 71 (28.0) 17 (14.9)  < 0.01
 N1 33 (11.4) 9 (7.7)   26 (10.2) 10 (8.8)  
 N2 111 (38.5) 72 (61.5)   98 (38.6) 65 (57.0)  
 N3 27 (9.3) 9 (7.7)   25 (9.8) 12 (10.5)  
Overall stage
 I 32 (11.1) 4 (3.4)  < 0.01 25 (9.8) 6 (5.2) 0.13
 II 28 (9.7) 9 (7.7)   25 (9.8) 8 (7.0)  
 III 38 (13.1) 10 (8.5)   31 (12.2) 11 (9.6)  
 IV 155 (53.8) 84 (71.8)   139 (54.7) 79 (69.3)  
Location
 Tonsil 131 (59.5) 89 (40.5)  < 0.01 115 (57.5) 85 (42.5)  < 0.01
 Tongue base 69 (82.1) 15 (17.9)   64 (80.0) 16 (20.0)  
 Soft palate 66 (91.7) 6 ( 8.3)   57 (90.5) 6 (9.5)  
 Unspecific 22 (75.9) 7 (24.1)   18 (72.0) 7 (28.0)